Reactome | K48polyUb-TRAF3 [cytosol]

K48polyUb-TRAF3 [cytosol]

Stable Identifier

R-HSA-936556

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

K48-polyubiquitin TRAF3

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Locations in the PathwayBrowser for interactor UniProt:Q13011 ECH1

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Literature References

PubMed ID	Title	Journal	Year
19893624	The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation Hiscott, J, Lin, R, Zhao, T, Mesplede, T, Ware, CF, Chuang, TH, Nakhaei, P, Sun, Q, Solis, M, Yang, L	PLoS Pathog	2009

External Reference Information

External Reference

UniProt:Q13114 TRAF3

Gene Names

TRAF3, CAP1, CRAF1, CAP-1, TRAFAMN

Chain

chain:1-568

Reference Genes

BioGPS Gene:7187 TRAF3

COSMIC (genes):CAP1 TRAF3

COSMIC (genes):TRAF3 TRAF3

CTD Gene:7187 TRAF3

dbSNP Gene:7187 TRAF3

ENSEMBL:ENSG00000131323 TRAF3

HGNC:12033 TRAF3

KEGG:hsa:7187 TRAF3

Monarch:7187 TRAF3

NCBI Gene:7187 TRAF3

OMIM:601896 TRAF3

UCSC:Q13114 TRAF3

Reference Transcript

Other Identifiers

11742091_a_at

11743501_a_at

11759502_at

16789080

208315_3p_x_at

208315_PM_x_at

208315_x_at

221571_PM_at

221571_at

3553338

3553346

3553358

3553359

3553360

3553361

3553363

3553364

3553365

3553367

3553368

3553370

3553373

3553374

3553378

3553379

3553380

3553381

3553382

3553383

3553384

3553386

3553388

37057_s_at

43952_at

7187

7977018

A_14_P118576

A_23_P37068

A_32_P89837

GE59008

GO:0000151

GO:0001817

GO:0002224

GO:0002376

GO:0003824

GO:0004842

GO:0005164

GO:0005515

GO:0005737

GO:0005739

GO:0005768

GO:0005829

GO:0006355

GO:0006915

GO:0007165

GO:0008063

GO:0008270

GO:0009898

GO:0010008

GO:0012501

GO:0016740

GO:0019899

GO:0019901

GO:0019903

GO:0030162

GO:0031410

GO:0031625

GO:0031996

GO:0032088

GO:0032481

GO:0032648

GO:0033209

GO:0034142

GO:0035631

GO:0035666

GO:0042802

GO:0042981

GO:0043122

GO:0043226

GO:0045087

GO:0046872

GO:0050688

GO:0051607

GO:0060337

GO:0061630

GO:0070534

GO:0098542

GO:0140096

GO:1902554

HMNXSV003033530

Hs.297660.1.S2_3p_at

ILMN_2383774

PH_hs_0015383

PH_hs_0038599

TC14000786.hg

TC14000789.hg

U15637_s_at

g4507678_3p_a_at

g4507678_3p_at

g4507678_3p_x_at

Participates

as a component of

K48polyUb-TRAF3:NIK [cytosol] (Homo sapiens)

as an output of

Negative regulation of DDX58/IFIH1 signaling by RNF216 (Homo sapiens)

Other forms of this molecule

K63polyUb-TRAF3 [cytosol]

TRAF3 [cytosol]

TRAF3 R118W [cytosol]

Inferred To

traf3 [cytosol] (Xenopus tropicalis)

Traf3 [cytosol] (Mus musculus)

Traf3 [cytosol] (Rattus norvegicus)

TRAF3 [cytosol] (Bos taurus)

TRAF3 [cytosol] (Canis familiaris)

TRAF3 [cytosol] (Gallus gallus)

TRAF3 [cytosol] (Sus scrofa)

Modified Residues

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_011535420.1, NP_663777.1, NP_663778.1, XP_016877106.1, XP_016877107.1, NP_001186356.1, NP_003291.2

OpenTargets

ENSG00000131323

ENSEMBL

ENSP00000445998, ENSP00000514678, ENST00000699894, ENSP00000454207, ENST00000392745, ENST00000539721, ENSP00000376500, ENST00000560371

HPA

ENSG00000131323-TRAF3

PRO

Q13114

Pharos - Targets

Q13114

GlyGen

Q13114

Orphanet

TRAF3

PDB

8T5P, 1KZZ, 1L0A, 2ECY, 1ZMS, 1RF3, 2GKW, 1FLL, 1FLK

Interactors (49)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99558 MAP3K14	5	Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.918	10
UniProt:Q92844 TANK	2	K63polyUb-TANK [cytosol] (R-HSA-5362480) TANK [cytosol] (R-HSA-933407)	0.87	8
UniProt:O95721 SNAP29	3	SNAP29 [azurophil granule membrane] (R-HSA-6799359) SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997)	0.742	6
UniProt:O43353 RIPK2	2	Ub-209-RIPK2 [cytosol] (R-HSA-706483) RIPK2 [cytosol] (R-HSA-168402)	0.72	6
UniProt:Q13546 RIPK1	20	RIPK1 [cytosol] (R-HSA-168651) RIPK1 [endosome membrane] (R-HSA-450326) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) p-S166-RIPK1 [cytosol] (R-HSA-5218872) p-S357-RIPK1 [cytosol] (R-HSA-9819116) p-S320-RIPK1 [cytosol] (R-HSA-9815498) K63,M1polyUb, p-T189-RIPK1 [cytosol] (R-HSA-9817377) polyUb-K377,K604,K634-RIPK1 [cytosol] (R-HSA-9818391) RIPK1(325-671) [cytosol] (R-HSA-5212671) RIPK1(1-324) [cytosol] (R-HSA-5212664) K63,M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) K63,Met1polyUb-p-S25-RIPK1 [cytosol] (R-HSA-9818793) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) RIPK1 [plasma membrane] (R-HSA-937073) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324N [cytosol] (R-HSA-9693930) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) K48polyUb-RIPK1 [cytosol] (R-HSA-6783308)	0.703	5
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) p-TBK1 [cytosol] (R-HSA-9008705) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397)	0.688	4
UniProt:P41212 ETV6	14	ETV6(1-384)-p-6Y-FLT3(573-993) fusion [cytosol] (R-HSA-9703308) ETV6(1-154)insGSFILG-p-6Y-FLT3(573-993) fusion [cytosol] (R-HSA-9703302) ETV6(1-336)insGCS-p-6Y-FLT3(573-993) fusion [cytosol] (R-HSA-9703305) ETV6(1-301)-p-6Y-FLT3(574-993) fusion [cytosol] (R-HSA-9703318) ETV6(1-384)-p-3Y-FLT3(659-1620) fusion [cytosol] (R-HSA-9703313) ETV6(1-154)insGSFILG-FLT3(573-993) fusion [cytosol] (R-HSA-9703312) ETV6(1-336)insGCS-FLT3(573-993) fusion [cytosol] (R-HSA-9703320) ETV6(1-384)-FLT3(573-993) fusion [cytosol] (R-HSA-9703307) ETV6(1-301)-FLT3(574-993) fusion [cytosol] (R-HSA-9703315) ETV6(1-384)-FLT3(569-993) fusion [cytosol] (R-HSA-9697944) ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane] (R-HSA-9673898) ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane] (R-HSA-9673893) p-11Y-ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane] (R-HSA-9673905) p-12Y-ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane] (R-HSA-9673912)	0.671	5
UniProt:Q9HAV5 EDA2R	1	EDA2R [plasma membrane] (R-HSA-5669018)	0.669	3
UniProt:P36941 LTBR	1	LTBR [plasma membrane] (R-HSA-5668750)	0.669	4
UniProt:O00463 TRAF5			0.659	4
UniProt:Q8TDR0 TRAF3IP1	2	TRAF3IP1 [ciliary tip] (R-HSA-5625404) TRAF3IP1 [cilium] (R-HSA-5617603)	0.639	8
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.573	4
UniProt:Q9UHJ6 SHPK	1	SHPK [cytosol] (R-HSA-8959710)	0.564	2
UniProt:Q96PC2 IP6K3	1	IP6K3 [cytosol] (R-HSA-1604594)	0.556	5
UniProt:Q17RL8 Q17RL8			0.556	3
IntAct:EBI-22505066 CCSB ORF ID			0.556	3
UniProt:Q0D2K3 RIPP1			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q86UB2 BIVM			0.556	6
UniProt:Q13114 TRAF3	4	K63polyUb-TRAF3 [cytosol] (R-HSA-936402) TRAF3 [cytosol] (R-HSA-914241) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 R118W [cytosol] (R-HSA-5602321)	0.556	5
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.556	3
UniProt:Q9Y547 HSPB11	2	HSPB11 [ciliary tip] (R-HSA-5625342) HSPB11 [cilium] (R-HSA-5617628)	0.556	3
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.556	3
UniProt:Q9UKD1 GMEB2			0.556	3
UniProt:Q8N9N2-2 ASCC1			0.556	3
UniProt:Q8NAM6 ZSCAN4	1	ZSCAN4 [nucleoplasm] (R-HSA-9816447)	0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:Q5T681 CJ062			0.556	3
UniProt:Q52MB2 CC184			0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:Q96HA1-2 POM121			0.556	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.556	3
UniProt:P28062-2 PSMB8			0.556	3
UniProt:Q6ZSB9 ZBT49			0.556	3
UniProt:Q8IYE1 CCD13			0.556	3
UniProt:Q15628 TRADD	1	TRADD [cytosol] (R-HSA-66376)	0.547	2
UniProt:Q01844 EWS			0.547	2
UniProt:P28908 TNFRSF8	1	TNFRSF8 [plasma membrane] (R-HSA-5668758)	0.527	2
UniProt:Q13011 ECH1	3	ECH1 [mitochondrial matrix] (R-HSA-9838037) ECH1(1-328) [peroxisomal matrix] (R-HSA-9033140) ECH1(1-328) [cytosol] (R-HSA-9033152)	0.527	2
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.527	3
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.527	3
UniProt:Q9UJT2 TSKS			0.527	2
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.524	2
UniProt:P25942 CD40			0.508	3
UniProt:Q9Y692 GMEB1			0.508	2
UniProt:P15314	1	Irf1 [nucleoplasm] (R-MMU-983456)	0.499	2
UniProt:A2APF7 A2APF7			0.499	2
UniProt:Q9QYP6 AZI2			0.499	2

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