Reactome | ATP1A1 [plasma membrane]

ATP1A1 [plasma membrane]

Stable Identifier

R-HSA-936850

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Sodium/potassium-transporting ATPase subunit alpha-1, AT1A1_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        ATP1A:ATP1B:FXYD binds cardiac glycosides (Homo sapiens)
        
        ATP1A:ATP1B:FXYD [plasma membrane] (Homo sapiens)
        
        ATP1A [plasma membrane] (Homo sapiens)
        
        ATP1A1 [plasma membrane] (Homo sapiens)
        
        ATP1A:ATP1B:FXYD:cardiac glycosides [plasma membrane] (Homo sapiens)
        
        ATP1A:ATP1B:FXYD [plasma membrane] (Homo sapiens)
        
        ATP1A [plasma membrane] (Homo sapiens)
        
        ATP1A1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P05023 ATP1A1

Gene Names

ATP1A1

Chain

propeptide:1-5, chain:6-1023

Reference Genes

BioGPS Gene:476 ATP1A1

COSMIC (genes):ATP1A1 ATP1A1

CTD Gene:476 ATP1A1

dbSNP Gene:476 ATP1A1

ENSEMBL:ENSG00000163399 ATP1A1

HGNC:799 ATP1A1

KEGG:hsa:476 ATP1A1

Monarch:476 ATP1A1

NCBI Gene:476 ATP1A1

OMIM:182310 ATP1A1

UCSC:P05023 ATP1A1

Reference Transcript

Other Identifiers

11717018_a_at

11717019_x_at

11747228_x_at

11754930_x_at

16669121

220948_PM_s_at

220948_s_at

2353479

2353480

2353488

2353489

2353490

2353492

2353493

2353495

2353496

2353497

2353498

2353499

2353500

2353501

2353502

2353503

2353504

2353505

2353506

2353507

2353508

2353510

2353511

2353515

2353518

2353519

2353521

2353525

2353527

2353529

2353533

2353534

2353535

2353536

2353537

2353538

2353540

2353544

2353545

2353546

2353547

2353548

2353549

2353552

2353553

32225_at

476

66929_at

7904254

87941_r_at

A_23_P1072

A_33_P3384272

GE62442

GO:0000166

GO:0002026

GO:0002028

GO:0003012

GO:0003013

GO:0003824

GO:0005215

GO:0005391

GO:0005515

GO:0005524

GO:0005783

GO:0005794

GO:0005886

GO:0005890

GO:0005929

GO:0006813

GO:0006814

GO:0006883

GO:0007231

GO:0008217

GO:0008289

GO:0008556

GO:0009410

GO:0010248

GO:0014069

GO:0016020

GO:0016323

GO:0016324

GO:0016328

GO:0016787

GO:0016791

GO:0016887

GO:0030007

GO:0030315

GO:0030424

GO:0030955

GO:0031090

GO:0031402

GO:0031410

GO:0031947

GO:0032991

GO:0034220

GO:0036126

GO:0036376

GO:0042383

GO:0042470

GO:0042995

GO:0043226

GO:0044325

GO:0045121

GO:0045822

GO:0045823

GO:0045989

GO:0046872

GO:0046982

GO:0051087

GO:0055078

GO:0055085

GO:0055119

GO:0060047

GO:0060342

GO:0070062

GO:0071383

GO:0086002

GO:0086009

GO:0086013

GO:0086064

GO:0140657

GO:1902600

GO:1903416

GO:1903561

GO:1990239

GO:1990573

HMNXSV003004575

HMNXSV003028230

HMNXSV003033511

ILMN_1731783

ILMN_1775566

ILMN_2415189

PH_hs_0024197

PH_hs_0032937

TC01001018.hg

g4502268_3p_a_at

Participates

as a member of

ATP1A [plasma membrane] (Homo sapiens)

Inferred To

ATP1A1 [plasma membrane] (Bos taurus)

ATP1A1 [plasma membrane] (Canis familiaris)

ATP1A1 [plasma membrane] (Gallus gallus)

ATP1A1 [plasma membrane] (Mus musculus)

ATP1A1 [plasma membrane] (Rattus norvegicus)

ATP1A1 [plasma membrane] (Sus scrofa)

atp1a1 [plasma membrane] (Xenopus tropicalis)

atp1a1a.1 [plasma membrane] (Danio rerio)

Cross References

Guide to Pharmacology - Targets

833

ENSEMBL

ENSP00000445306, ENSP00000295598, ENST00000537345, ENST00000369496, ENSP00000358508, ENST00000295598

OpenTargets

ENSG00000163399

HPA

ENSG00000163399-ATP1A1

PRO

P05023

Pharos - Targets

P05023

GlyGen

P05023

Orphanet

ATP1A1

HMDB Protein

HMDBP01387

PDB

7E1Z, 7E20, 7E21

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.643	3
UniProt:Q92597 NDRG1	1	NDRG1 [cytosol] (R-HSA-5628834)	0.564	2
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.527	5
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.527	2
UniProt:P0DTC4 E	9	Ub-3xPalmC-E [virion membrane] (R-COV-9698416) Ub-3xPalmC-E [endocytic vesicle membrane] (R-COV-9698422) Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698420) Ub-3xPalmC-E [Golgi membrane] (R-COV-9694687) Ub-3xPalmC-E [endoplasmic reticulum membrane] (R-COV-9694465) Ub-3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694423) 3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694305) nascent E [endoplasmic reticulum lumen] (R-COV-9694312) N-glycan E [endoplasmic reticulum lumen] (R-COV-9694754)	0.527	2
UniProt:P0DTC7 7a	5	7a [endolysosome membrane] (R-COV-9755945) 7a [endoplasmic reticulum membrane] (R-COV-9727308) 7a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694750) 7a [endocytic vesicle membrane] (R-COV-9694645) 7a [virion membrane] (R-COV-9694648)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.462	2

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