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activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane]
Stable Identifier
R-HSA-936954
Type
Complex
Species
Homo sapiens
Compartment
endosome membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Homo sapiens)
Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Homo sapiens)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Homo sapiens)
Activation of TAK1 complex bound to activated TLR4 complex (Homo sapiens)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
16115877
Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation
Fitzgerald, KA
,
Cusson-Hermance, N
,
Khurana, S
,
Kelliher, MA
,
Lee, TH
J Biol Chem
2005
Participants
components
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
(Homo sapiens)
x 2
K63polyUb [cytosol]
(Homo sapiens)
x 2
TAB1:TAB2,TAB3:TAK1 [cytosol]
(Homo sapiens)
Participates
as an output of
Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Homo sapiens)
as an input of
Activation of TAK1 complex bound to activated TLR4 complex (Homo sapiens)
Inferred To
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane]
(Bos taurus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane]
(Canis familiaris)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane]
(Gallus gallus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane]
(Mus musculus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane]
(Rattus norvegicus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane]
(Sus scrofa)
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