activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane]

Stable Identifier
R-HSA-936970
Type
Complex
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
19656901 Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling

Chen, H, Piao, W, Fitzgerald, KA, Li, L, Diaz, MA, Medvedev, AE, Wahl, LM, Song, C

J. Leukoc. Biol. 2009
17823124 Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF

Muraille, E, Close, P, Brown, K, Siebenlist, U, Chau, TL, Chapelle, JP, Piette, J, Warnier, M, Gatot, JS, Patrascu, F, Dejardin, E, Chariot, A, Gioia, R

J. Biol. Chem. 2007
14530355 Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling

Kawai, T, Takeda, K, Sato, S, Akira, S, Watanabe, Y, Yamamoto, M, Sugiyama, M

J. Immunol. 2003
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