Reactome | K63polyUb-TRAF6 [plasma membrane]

K63polyUb-TRAF6 [plasma membrane]

Stable Identifier

R-HSA-936980

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

K6 polyubiquitinated TRAF6

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Literature References

PubMed ID	Title	Journal	Year
17135271	Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation Lamothe, B, Wu, H, Darnay, BG, Besse, A, Campos, AD, Webster, WK	J Biol Chem	2007

External Reference Information

External Reference

UniProt:Q9Y4K3 TRAF6

Gene Names

TRAF6, RNF85

Chain

chain:1-522

Reference Genes

BioGPS Gene:7189 TRAF6

COSMIC (genes):TRAF6 TRAF6

CTD Gene:7189 TRAF6

dbSNP Gene:7189 TRAF6

ENSEMBL:ENSG00000175104 TRAF6

ENSEMBL_homo_sapiens_GENE:ENSG00000175104.15 TRAF6

HGNC:12036 TRAF6

KEGG Gene (Homo sapiens):7189 TRAF6

Monarch:7189 TRAF6

NCBI Gene:7189 TRAF6

OMIM:602355 TRAF6

UCSC:Q9Y4K3 TRAF6

Reference Transcript

Other Identifiers

11744243_a_at

1209_at

16737401

205558_PM_at

205558_at

227264_PM_at

227264_at

3290612

3290616

3369887

3369889

3369891

3369892

3369893

3369894

3369895

3369896

3369898

3369899

3369902

3369903

3369904

3369905

3369906

3369907

3369913

3369914

53334_at

61369_at

7189

74236_at

7947540

82386_at

A_23_P75921

A_32_P192984

GE59433

GO:0000045

GO:0000122

GO:0000209

GO:0001503

GO:0001701

GO:0001843

GO:0002223

GO:0002376

GO:0002637

GO:0002726

GO:0002753

GO:0002755

GO:0003824

GO:0004842

GO:0005164

GO:0005515

GO:0005634

GO:0005737

GO:0005768

GO:0005811

GO:0005829

GO:0005886

GO:0005938

GO:0006351

GO:0006355

GO:0006914

GO:0006955

GO:0006974

GO:0007155

GO:0007165

GO:0007249

GO:0007250

GO:0008270

GO:0009887

GO:0009898

GO:0010008

GO:0012501

GO:0016567

GO:0016740

GO:0019886

GO:0019899

GO:0023052

GO:0030154

GO:0030316

GO:0031234

GO:0031398

GO:0031410

GO:0031624

GO:0031625

GO:0031663

GO:0031666

GO:0032147

GO:0032481

GO:0032735

GO:0032743

GO:0032755

GO:0032813

GO:0032991

GO:0033209

GO:0034138

GO:0034142

GO:0034450

GO:0035556

GO:0035631

GO:0035666

GO:0036211

GO:0038061

GO:0038095

GO:0038172

GO:0038173

GO:0042088

GO:0042102

GO:0042475

GO:0042802

GO:0042826

GO:0042981

GO:0043011

GO:0043122

GO:0043123

GO:0043226

GO:0043422

GO:0043507

GO:0045087

GO:0045453

GO:0045672

GO:0045892

GO:0045944

GO:0046849

GO:0046872

GO:0048468

GO:0048471

GO:0048584

GO:0048856

GO:0050852

GO:0051091

GO:0051092

GO:0051865

GO:0061630

GO:0070498

GO:0070534

GO:0070555

GO:0071222

GO:0071345

GO:0097400

GO:0098542

GO:0140096

GO:0140374

GO:1904996

GO:2000679

HMNXSV003018702

Hs.296272.0.A1_3p_at

ILMN_1700353

ILMN_1783910

ILMN_2392143

PH_hs_0005066

PH_hs_0037121

TC11001560.hg

TC11003120.hg

U78798_at

g4759253_3p_at

Participates

as a component of

p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] (Homo sapiens)

Other forms of this molecule

K48polyUb-TRAF6 [cytosol]

PolyUb-TRAF6 [cytosol]

TRAF6 [endosome membrane]

K63polyUb-TRAF6 [endosome membrane]

TRAF6 [cytosol]

K63polyUb-TRAF6 [cytosol]

TRAF6 [plasma membrane]

Inferred To

TRAF6 [plasma membrane] (Bos taurus)

TRAF6 [plasma membrane] (Canis familiaris)

TRAF6 [plasma membrane] (Gallus gallus)

TRAF6 [plasma membrane] (Sus scrofa)

Traf6 [plasma membrane] (Drosophila melanogaster)

Traf6 [plasma membrane] (Mus musculus)

Traf6 [plasma membrane] (Rattus norvegicus)

traf6 [plasma membrane] (Xenopus tropicalis)

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [plasma membrane]) at 124

Coordinate

124

Modification

K63polyUb [plasma membrane]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_665802.1, NP_004611.1

OpenTargets

ENSG00000175104

IntEnz

2.3.2.27

GeneCards

Q9Y4K3

HPA

ENSG00000175104-TRAF6

Ensembl

ENSP00000433623, ENSP00000337853, ENSG00000175104, ENST00000348124, ENST00000526995

PRO

Q9Y4K3

Pharos - Targets

Q9Y4K3

Orphanet

21836

PDB

3HCS, 2JMD, 1LB4, 3HCT, 7L3L, 3HCU, 5ZUJ, 4Z8M, 6A33, 2ECI, 1LB6, 1LB5, 8HZ2

Interactors (77)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.939	20
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.919	11
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.905	10
UniProt:O00463 TRAF5			0.879	15
UniProt:P61088 UBE2N	5	Ub-C87-UBE2N [nucleoplasm] (R-HSA-8943013) K63polyUb-C87-UBE2N [nucleoplasm] (R-HSA-6790511) UBE2N [nucleoplasm] (R-HSA-5682541) Ub-C87-UBE2N [cytosol] (R-HSA-8864210) UBE2N [cytosol] (R-HSA-206072)	0.847	9
UniProt:O43187 IRAK2	6	IRAK2 [endosome membrane] (R-HSA-975116) p-IRAK2 [endosome membrane] (R-HSA-975187) IRAK2 [plasma membrane] (R-HSA-937014) IRAK2 [cytosol] (R-HSA-772534) p-IRAK2 [plasma membrane] (R-HSA-936949) p-IRAK2 [cytosol] (R-HSA-446636)	0.809	5
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.797	8
UniProt:P51617 IRAK1	14	K63polyUb-hp-IRAK1 [endosome membrane] (R-HSA-975112) p-S376,T387-IRAK1 [cytosol] (R-HSA-446687) p-S,T-IRAK1 [cytosol] (R-HSA-3149574) K63polyUb-hp-IRAK1 [cytosol] (R-HSA-451565) p-T209-IRAK1 [endosome membrane] (R-HSA-975189) p-T209,T387-IRAK1 [endosome membrane] (R-HSA-975117) IRAK1 [endosome membrane] (R-HSA-975127) p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-HSA-975157) IRAK1 [plasma membrane] (R-HSA-937045) p-T209-IRAK1 [plasma membrane] (R-HSA-937031) p-T209,T387-IRAK1 [plasma membrane] (R-HSA-166279) p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-HSA-937011) p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-HSA-446682) IRAK1 [cytosol] (R-HSA-446639)	0.77	4
IntAct:EBI-4399559 UBIQ			0.77	5
UniProt:P62195 PSMC5	2	PSMC5 [nucleoplasm] (R-HSA-174312) PSMC5 [cytosol] (R-HSA-68780)	0.758	4
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.718	6
UniProt:Q8N1B4 VPS52	1	VPS52 [trans-Golgi network membrane] (R-HSA-6811029)	0.718	6
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.71	4
UniProt:P62837 UBE2D2	4	Ub-C85-UBE2D2 [nucleoplasm] (R-HSA-8864153) UBE2D2 [nucleoplasm] (R-HSA-8852067) UBE2D2 [cytosol] (R-HSA-934628) Ub-C85-UBE2D2 [cytosol] (R-HSA-8864214)	0.708	5
UniProt:Q96CG3 TIFA	2	TIFA [cytosol] (R-HSA-451582) p-T9-TIFA [cytosol] (R-HSA-9645512)	0.702	6
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.702	3
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.688	4
UniProt:Q9UDY8 MALT1	1	MALT1 [cytosol] (R-HSA-202461)	0.688	5
UniProt:Q9NYJ8 TAB2	4	TAB2 [cytosol] (R-HSA-168117) TAB2 [endosome membrane] (R-HSA-450279) TAB2 [plasma membrane] (R-HSA-168116) TAB2 [nucleoplasm] (R-HSA-1253323)	0.678	3
UniProt:Q9Y616 IRAK3	1	IRAK3 [cytosol] (R-HSA-166103)	0.675	4
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.675	4
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.675	4
UniProt:Q9HAV5 EDA2R	1	EDA2R [plasma membrane] (R-HSA-5669018)	0.669	3
UniProt:O43318 MAP3K7	10	PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) MAP3K7 [plasma membrane] (R-HSA-9012677) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) p-MAP3K7 [cytosol] (R-HSA-168163) p-T187-MAP3K7 [cytosol] (R-HSA-206014) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.669	3
UniProt:O43734 CIKS			0.666	4
UniProt:P61077 UBE2D3	3	UBE2D3 [nucleoplasm] (R-HSA-205341) UBE2D3 [cytosol] (R-HSA-934630) Ub-C85-UBE2D3 [cytosol] (R-HSA-8864191)	0.658	3
UniProt:Q9UKE5 TNIK	1	TNIK [cytosol] (R-HSA-3214889)	0.591	3
UniProt:P25942 CD40			0.59	2
UniProt:P07174 Ngfr	8	Ngfr [nucleoplasm] (R-RNO-197473) Ngfr [plasma membrane] (R-RNO-194509) Ngfr [cytosol] (R-RNO-194458) Ngfr [endosome] (R-RNO-209541) Ngfr [plasma membrane] (R-RNO-194476) Ngfr [extracellular region] (R-RNO-194470) Tumor necrosis factor receptor superfamily member 16 [plasma membrane] (R-RNO-193863) Ngfr [plasma membrane] (R-RNO-193664)	0.589	2
UniProt:P28074 PSMB5	4	PSMB5(1-59) [cytosol] (R-HSA-9908134) pro-PSMB5 [cytosol] (R-HSA-9908135) PSMB5 [nucleoplasm] (R-HSA-174344) PSMB5 [cytosol] (R-HSA-68753)	0.589	2
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.589	2
UniProt:Q9UNM6 PSMD13	5	PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [cytosol] (R-HSA-68794)	0.589	2
UniProt:Q15008 PSMD6	5	PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [cytosol] (R-HSA-68804)	0.589	2
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [secretory granule lumen] (R-HSA-6801039) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [extracellular region] (R-HSA-6806191) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [cytosol] (R-HSA-1181251)	0.589	2
UniProt:O00232 PSMD12	5	PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [cytosol] (R-HSA-68792)	0.589	2
UniProt:P51665 PSMD7	5	PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [cytosol] (R-HSA-68806)	0.589	2
UniProt:P40939 HADHA	1	HADHA [mitochondrial inner membrane] (R-HSA-77264)	0.589	2
UniProt:P62191 PSMC1	2	PSMC1 [nucleoplasm] (R-HSA-174338) PSMC1 [cytosol] (R-HSA-68768)	0.589	2
UniProt:Q13200 PSMD2	5	PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [cytosol] (R-HSA-68796)	0.589	2
UniProt:Q14257 RCN2			0.589	2
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.556	3
UniProt:Q8IWQ3-3 BRSK2			0.556	3
UniProt:Q9UNA4 POLI	1	POLI [nucleoplasm] (R-HSA-5656133)	0.556	3
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.556	3
UniProt:O94888 WIPF1	2	UBXN7 [cytosol] (R-HSA-8956071) ub-UBXN7 [cytosol] (R-HSA-9755305)	0.556	3
UniProt:P43405-2 P434052			0.556	3
UniProt:P15732	2	UBC5 [cytosol] (R-SCE-8864160-2) UBC5 [cytosol] (R-SCE-174236-2)	0.556	3
UniProt:Q9HAC8 UBTD1			0.556	3
UniProt:Q8N3F0 MTURN			0.556	3
UniProt:Q8NA54 IQUB			0.556	3
UniProt:Q96DC9 OTUB2	2	OTUB2 [cytosol] (R-HSA-933410) OTUB2 [nucleoplasm] (R-HSA-6783260)	0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:Q5VVQ6 YOD1	1	YOD1 [cytosol] (R-HSA-6781909)	0.556	5
UniProt:P24278 ZBT25			0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.556	3
UniProt:Q8WWZ3 EDARADD	1	EDARADD [cytosol] (R-HSA-5675659)	0.556	5
UniProt:Q8TD23 ZNF675	1	ZNF675 [nucleoplasm] (R-HSA-2248874)	0.543	4
UniProt:P99999 CYCS	6	AcK-CYCS [mitochondrial intermembrane space] (R-HSA-5688308) Cytochrome c (oxidised) [mitochondrial inner membrane] (R-HSA-352607) CYCS [cytosol] (R-HSA-53259) CYCS [mitochondrial intermembrane space] (R-HSA-114244) apo-CYCS [mitochondrial inner membrane] (R-HSA-352608) Cytochrome c (reduced) [mitochondrial inner membrane] (R-HSA-352609)	0.536	2
UniProt:Q99558 MAP3K14	5	p-T559-MAP3K14 [cytosol] (R-HSA-5668531) K48polyUb-NIK [cytosol] (R-HSA-5668525) Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187)	0.536	2
UniProt:Q9Y3C0 WASC3			0.527	2
UniProt:Q15750 TAB1	6	TAB1(445-504) [cytosol] (R-HSA-9729691) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1 [endosome membrane] (R-HSA-450238) TAB1 [cytosol] (R-HSA-167923)	0.527	2
UniProt:Q9Y2V7 COG6	2	COG6 [Golgi membrane] (R-HSA-2980958) COG6 [trans-Golgi network membrane] (R-HSA-6813872)	0.527	2
UniProt:Q9Y6C2 EMILIN1	1	EMILIN1 [extracellular region] (R-HSA-2161355)	0.527	2
UniProt:O95721 SNAP29	3	SNAP29 [azurophil granule membrane] (R-HSA-6799359) SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997)	0.527	3
UniProt:P51668 UBE2D1	3	UBE2D1 [cytosol] (R-HSA-174236) UBE2D1 [nucleoplasm] (R-HSA-174197) Ub-C85-UBE2D1 [cytosol] (R-HSA-8864160)	0.527	2
UniProt:Q05D60 DEUP1			0.527	2
UniProt:P10221 ITP			0.524	3
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.524	2
UniProt:Q01220 A52			0.524	2
UniProt:P98170 XIAP	3	XIAP [nucleoplasm] (R-HSA-3322366) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [cytosol] (R-HSA-50849)	0.519	2
UniProt:Q8V2D1 Q8V2D1			0.518	3
UniProt:O75385 ULK1	7	ULK1 [recycling endosome] (R-HSA-8854761) p-S758-ULK1 [cytosol] (R-HSA-5672131) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145)	0.499	2
UniProt:Q9C0C7-3 AMBRA1			0.499	2
UniProt:P14778 IL1R1	1	IL1R1 [plasma membrane] (R-HSA-197595)	0.499	2
UniProt:O14836 TNFRSF13B	1	TAC1 [plasma membrane] (R-HSA-5668752)	0.462	2

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