Reactome | K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]

K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]

Stable Identifier

R-HSA-937016

Type

Complex

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

activated TLR4:TRIF:K63pUb-RIP1

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
16115877	Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation Fitzgerald, KA, Cusson-Hermance, N, Khurana, S, Kelliher, MA, Lee, TH	J Biol Chem	2005
15814722	Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif Offermann, MK, Kaiser, WJ	J Immunol	2005

Participants

components

Participates

as a component of

CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)

as an input of

IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Homo sapiens)

as an output of

K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)

This entity regulates

Negatively

TLR4-induced ripoptosome assembly (Homo sapiens)

Inferred To

K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)

K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)

K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)

K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)

K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Rattus norvegicus)

K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)

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