Both IRAK1 and IRAK4 were shown to phosphorylate Pellino isoforms in vitro. The phosphorylation of Pellino proteins is a necessary step in enhancing of their E3 ubiquitin ligase activity. It remains unclear whether IRAK1(as shown here), IRAK4, or both protein kinases mediate the activation of Pellino isoforms in vivo.
Peggie, M, Campbell, DG, Carrick, E, Smith, H, Vandermoere, F, Cohen, P
Hanly, JA, Butler, MP, Moynagh, PN
Peggie, M, Ordureau, A, Carrick, E, Morrice, N, Windheim, M, Smith, H, Cohen, P
protein kinase activity of TRAF6:hp-IRAK1:Pellino [plasma membrane]
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