IRAK1 phosphorylates Pellino

Stable Identifier
R-HSA-937034
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Both IRAK1 and IRAK4 were shown to phosphorylate Pellino isoforms in vitro. The phosphorylation of Pellino proteins is a necessary step in enhancing of their E3 ubiquitin ligase activity. It remains unclear whether IRAK1(as shown here), IRAK4, or both protein kinases mediate the activation of Pellino isoforms in vivo.

Literature References
Participants
Participates
Catalyst Activity

protein kinase activity of TRAF6:hp-IRAK1:Pellino [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!