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RYR2 [sarcoplasmic reticulum membrane]
Stable Identifier
R-HSA-937283
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
sarcoplasmic reticulum membrane
Synonyms
Ryanodine receptor 2, RYR2_HUMAN
Locations in the PathwayBrowser
Expand all
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Homo sapiens)
RYR tetramer:FKBP1B tetramer:CASQ polymer:TRDN:junctin [sarcoplasmic reticulum membrane] (Homo sapiens)
RYR tetramers [sarcoplasmic reticulum membrane] (Homo sapiens)
RYR2 tetramer [sarcoplasmic reticulum membrane] (Homo sapiens)
RYR2 [sarcoplasmic reticulum membrane] (Homo sapiens)
RYR tetramers [sarcoplasmic reticulum membrane] (Homo sapiens)
RYR2 tetramer [sarcoplasmic reticulum membrane] (Homo sapiens)
RYR2 [sarcoplasmic reticulum membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
Stimuli-sensing channels (Homo sapiens)
RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Homo sapiens)
RYR tetramer:FKBP1B tetramer:CASQ polymer:TRDN:junctin [sarcoplasmic reticulum membrane] (Homo sapiens)
RYR tetramers [sarcoplasmic reticulum membrane] (Homo sapiens)
RYR2 tetramer [sarcoplasmic reticulum membrane] (Homo sapiens)
RYR2 [sarcoplasmic reticulum membrane] (Homo sapiens)
RYR tetramers [sarcoplasmic reticulum membrane] (Homo sapiens)
RYR2 tetramer [sarcoplasmic reticulum membrane] (Homo sapiens)
RYR2 [sarcoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92736 RYR2
Gene Names
RYR2
Chain
chain:1-4967
Reference Genes
BioGPS Gene:6262 RYR2
COSMIC (genes):RYR2 RYR2
CTD Gene:6262 RYR2
dbSNP Gene:6262 RYR2
ENSEMBL:ENSG00000198626 RYR2
HGNC:10484 RYR2
KEGG:hsa:6262 RYR2
Monarch:6262 RYR2
NCBI Gene:6262 RYR2
OMIM:180902 RYR2
UCSC:Q92736 RYR2
Reference Transcript
RefSeq:XM_006711805.3 RYR2
RefSeq:NM_001035.2 RYR2
Other Identifiers
11726496_at
11752915_a_at
11753014_a_at
11763522_a_at
16679142
207557_PM_s_at
207557_s_at
214044_PM_at
214044_at
2387127
2387128
2387181
2387189
2387202
2387205
2387208
2387209
2387212
2387213
2387219
2387221
2387222
2387223
2387224
2387225
2387226
2387228
2387236
2387237
2387238
2387239
2387240
2387241
2387244
2387247
2387248
2387251
2387252
2387256
2387258
2387260
2387261
2387262
2387263
2387264
2387266
2387267
2387274
2387275
2387276
2387278
2387279
2387280
2387283
2387284
2387285
2387286
2387288
2387289
2387290
2387292
2387293
2387294
2387296
2387298
2387299
2387301
2387302
2387303
2387304
2387305
2387306
2387309
2387310
2387313
2387314
2387315
2387316
2387317
2387318
2387320
2387321
2387322
2387323
2387324
2387325
2387326
2387327
2387328
2387329
2387330
2387332
2387334
2387335
2387336
2387337
2387338
2387340
2387343
2387344
2387346
2387348
2387351
2387352
2387353
2387354
2387355
2387356
2387357
2387358
2387360
2387361
2387363
2387364
2387365
2387366
2387367
2387368
2387369
2387371
2387372
2387376
2387377
2387379
2387381
2387382
2387383
2387384
2387385
2387386
2387387
2387388
38263_at
6262
7910792
A_14_P129287
A_14_P137572
A_23_P137797
A_33_P3251727
GE60207
GE681401
GO:0001666
GO:0002027
GO:0003012
GO:0003143
GO:0003220
GO:0003300
GO:0005215
GO:0005216
GO:0005219
GO:0005262
GO:0005509
GO:0005513
GO:0005515
GO:0005516
GO:0005783
GO:0005790
GO:0005886
GO:0006811
GO:0006816
GO:0006874
GO:0006941
GO:0008324
GO:0010460
GO:0010881
GO:0010882
GO:0012501
GO:0014701
GO:0014808
GO:0014850
GO:0015085
GO:0015278
GO:0016020
GO:0016529
GO:0019722
GO:0019899
GO:0019901
GO:0023052
GO:0030017
GO:0030018
GO:0031000
GO:0032991
GO:0033017
GO:0034236
GO:0034237
GO:0034704
GO:0035994
GO:0042383
GO:0042802
GO:0043226
GO:0043924
GO:0044325
GO:0048763
GO:0051209
GO:0051284
GO:0051480
GO:0051649
GO:0051775
GO:0055085
GO:0055117
GO:0060048
GO:0060402
GO:0070296
GO:0070588
GO:0071313
GO:0071872
GO:0072599
GO:0086005
GO:0086029
GO:0086064
GO:0097050
GO:0097159
GO:0097553
GO:0098735
GO:0098904
GO:0098907
GO:0098910
GO:0098911
HMNXSV003018396
HMNXSV003031804
Hs.332699.0.A1_3p_at
ILMN_1760798
PH_hs_0005062
TC01001957.hg
X98330_at
g4506756_3p_s_at
Participates
as a component of
RYR2 tetramer [sarcoplasmic reticulum membrane] (Homo sapiens)
Inferred To
Ryr2 [sarcoplasmic reticulum membrane]
(Mus musculus)
Ryr2 [sarcoplasmic reticulum membrane]
(Rattus norvegicus)
RYR2 [sarcoplasmic reticulum membrane]
(Bos taurus)
RYR2 [sarcoplasmic reticulum membrane]
(Canis familiaris)
RYR2 [sarcoplasmic reticulum membrane]
(Sus scrofa)
Cross References
Guide to Pharmacology - Targets
748
OpenTargets
ENSG00000198626
ENSEMBL
ENSP00000355533
,
ENST00000366574
HPA
ENSG00000198626-RYR2
PRO
Q92736
Pharos - Targets
Q92736
Orphanet
RYR2
GlyGen
Q92736
PDB
8UXM
,
7UA3
,
8UXF
,
7UA5
,
8UXL
,
7UA4
,
7UA1
,
8UXG
,
8UXH
,
8UXI
,
4JKQ
,
8UQ2
,
7UA9
,
7KL5
,
8UQ3
,
7U9T
,
7U9Q
,
7U9R
,
7U9X
,
6Y4O
,
7U9Z
,
6Y4P
,
8UXC
,
8UXE
,
8UQ4
,
8UQ5
HMDB Protein
HMDBP07975
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q00987 MDM2
11
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
MDM2 [cytosol]
(R-HSA-198644)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
MDM2 [plasma membrane]
(R-HSA-416843)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
0.524
2
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