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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
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Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
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ORCID Integration Project
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UBC(381-456) [cytosol]
Stable Identifier
R-HSA-939191
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ubiquitin (UBC 6)
Locations in the PathwayBrowser for interactor ChEBI:167176 GRL-0617
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
OTULIN,USP5 cleaves UBC yielding ubiquitin (Homo sapiens)
UBC(381-456) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P0CG48 UBC
Gene Names
UBC
Chain
chain:1-76, chain:77-152, chain:153-228, chain:229-304, chain:305-380, chain:381-456, chain:457-532, chain:533-608, chain:609-684, propeptide:-
Reference Genes
BioGPS Gene:7316 UBC
COSMIC (genes):UBC UBC
CTD Gene:7316 UBC
dbSNP Gene:7316 UBC
ENSEMBL:ENSG00000150991 UBC
ENSEMBL_homo_sapiens_GENE:ENSG00000150991.16 UBC
HGNC:12468 UBC
KEGG Gene (Homo sapiens):7316 UBC
Monarch:7316 UBC
NCBI Gene:7316 UBC
OMIM:191340 UBC
UCSC:P0CG48 UBC
Reference Transcript
RefSeq:NM_021009.6 UBC
Other Identifiers
11744653_x_at
11755503_x_at
11758319_x_at
1366_i_at
1367_f_at
16772172
208980_PM_s_at
208980_s_at
211296_PM_x_at
211296_x_at
32334_f_at
32335_r_at
3476742
3476743
3476744
3476745
3476746
3476747
3476748
3476749
3476750
3476751
3476752
3476753
3476754
3476755
3476756
3476757
3476758
3476759
3476760
3476761
3476762
3476763
3476764
3476765
3476766
3476767
3476768
3476769
3476770
3476771
3476772
3476773
3476774
3476775
3476776
3476777
3476778
7316
7967563
A_23_P329740
A_24_P266880
GE519044
GO:0002020
GO:0003723
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005741
GO:0005768
GO:0005783
GO:0005789
GO:0005829
GO:0005886
GO:0010008
GO:0016020
GO:0016567
GO:0019941
GO:0030163
GO:0030666
GO:0031386
GO:0031410
GO:0031625
GO:0031982
GO:0036211
GO:0043226
GO:0070062
HMNXSV003045710
ILMN_1891922
ILMN_2038773
ILMN_2252160
ILMN_2331501
M26880_at
PH_hs_0006671
PH_hs_0030809
TC12002099.hg
g2647407_3p_a_at
g340067_3p_x_at
Participates
as an output of
OTULIN,USP5 cleaves UBC yielding ubiquitin (Homo sapiens)
as a member of
Ub [cytosol] (Homo sapiens)
Other forms of this molecule
UBC(381-456) [endocytic vesicle membrane]
UBC(533-608) [endocytic vesicle membrane]
UBC(609-684) [endocytic vesicle membrane]
UBC(457-532) [endocytic vesicle membrane]
UBC(153-228) [endocytic vesicle membrane]
UBC(305-380) [endocytic vesicle membrane]
UBC(229-304) [endocytic vesicle membrane]
UBC(77-152) [endocytic vesicle membrane]
UBC(1-76) [endocytic vesicle membrane]
Ub-565-UBC(533-608) [mitochondrial outer membrane]
Ub-337-UBC(305-380) [mitochondrial outer membrane]
Ub-185-UBC(153-228) [mitochondrial outer membrane]
Ub-261-UBC(229-304) [mitochondrial outer membrane]
Ub-413-UBC(381-456) [mitochondrial outer membrane]
Ub-109-UBC(77-152) [mitochondrial outer membrane]
Ub-641-UBC(609-684) [mitochondrial outer membrane]
Ub-33-UBC(1-76) [mitochondrial outer membrane]
Ub-489-UBC(457-532) [mitochondrial outer membrane]
Ub-291-UBC(229-304) [mitochondrial outer membrane]
Ub-595-UBC(533-608) [mitochondrial outer membrane]
Ub-443-UBC(381-456) [mitochondrial outer membrane]
Ub-139-UBC(77-152) [mitochondrial outer membrane]
Ub-63-UBC(1-76) [mitochondrial outer membrane]
Ub-671-UBC(609-684) [mitochondrial outer membrane]
Ub-519-UBC(457-532) [mitochondrial outer membrane]
Ub-367-UBC(305-380) [mitochondrial outer membrane]
Ub-215-UBC(153-228) [mitochondrial outer membrane]
Ub-386-UBC(381-456) [mitochondrial outer membrane]
Ub-6-UBC(1-76) [mitochondrial outer membrane]
Ub-310-UBC(305-380) [mitochondrial outer membrane]
Ub-234-UBC(229-304) [mitochondrial outer membrane]
Ub-614-UBC(609-684) [mitochondrial outer membrane]
Ub-462-UBC(457-532) [mitochondrial outer membrane]
Ub-538-UBC(533-608) [mitochondrial outer membrane]
Ub-158-UBC(153-228) [mitochondrial outer membrane]
Ub-82-UBC(77-152) [mitochondrial outer membrane]
Ub-315-UBC(305-380) [mitochondrial outer membrane]
Ub-163-UBC(153-228) [mitochondrial outer membrane]
Ub-543-UBC(533-608) [mitochondrial outer membrane]
Ub-239-UBC(229-304) [mitochondrial outer membrane]
Ub-619-UBC(609-684) [mitochondrial outer membrane]
Ub-467-UBC(457-532) [mitochondrial outer membrane]
Ub-11-UBC(1-76) [mitochondrial outer membrane]
Ub-391-UBC(381-456) [mitochondrial outer membrane]
Ub-87-UBC(77-152) [mitochondrial outer membrane]
Ub-656-UBC(609-684) [mitochondrial outer membrane]
Ub-124-UBC(77-152) [mitochondrial outer membrane]
Ub-428-UBC(381-456) [mitochondrial outer membrane]
Ub-48-UBC(1-76) [mitochondrial outer membrane]
Ub-504-UBC(457-532) [mitochondrial outer membrane]
Ub-200-UBC(153-228) [mitochondrial outer membrane]
Ub-580-UBC(533-608) [mitochondrial outer membrane]
Ub-276-UBC(229-304) [mitochondrial outer membrane]
Ub-352-UBC(305-380) [mitochondrial outer membrane]
Ub-29-UBC(1-76) [mitochondrial outer membrane]
Ub-181-UBC(153-228) [mitochondrial outer membrane]
Ub-485-UBC(457-532) [mitochondrial outer membrane]
Ub-333-UBC(305-380) [mitochondrial outer membrane]
Ub-637-UBC(609-684) [mitochondrial outer membrane]
Ub-105-UBC(77-152) [mitochondrial outer membrane]
Ub-257-UBC(229-304) [mitochondrial outer membrane]
Ub-561-UBC(533-608) [mitochondrial outer membrane]
Ub-635-UBC(609-684) [mitochondrial outer membrane]
Ub-103-UBC(77-152) [mitochondrial outer membrane]
Ub-255-UBC(229-304) [mitochondrial outer membrane]
Ub-483-UBC(457-532) [mitochondrial outer membrane]
Ub-27-UBC(1-76) [mitochondrial outer membrane]
Ub-331-UBC(305-380) [mitochondrial outer membrane]
Ub-179-UBC(153-228) [mitochondrial outer membrane]
Ub-409-UBC(381-456) [mitochondrial outer membrane]
Ub-559-UBC(533-608) [mitochondrial outer membrane]
N6-glycyl-L-lysine-UBC(457-532) [cytosol]
N6-glycyl-L-lysine-UBC(609-684) [cytosol]
N6-glycyl-L-lysine-UBC(229-304) [cytosol]
N6-glycyl-L-lysine-UBC(533-608) [cytosol]
N6-glycyl-L-lysine-UBC(153-228) [cytosol]
N6-glycyl-L-lysine-UBC(305-380) [cytosol]
N6-glycyl-L-lysine-UBC(77-152) [cytosol]
N6-glycyl-L-lysine-UBC(1-76) [cytosol]
N6-glycyl-L-lysine-UBC(381-456) [cytosol]
adenylatedG608-UBC(533-608) [nucleoplasm]
adenylatedG380-UBC(305-380) [nucleoplasm]
adenylatedG532-UBC(457-532) [nucleoplasm]
adenylatedG304-UBC(229-304) [nucleoplasm]
adenylatedG152-UBC(77-152) [nucleoplasm]
adenylatedG684-UBC(609-684) [nucleoplasm]
adenylatedG228-UBC(153-228) [nucleoplasm]
adenylatedG76-UBC(1-76) [nucleoplasm]
adenylatedG456-UBC(381-456) [nucleoplasm]
UBC [cytosol]
adenylatedG380-UBC(305-380) [cytosol]
adenylatedG608-UBC(533-608) [cytosol]
adenylatedG76-UBC(1-76) [cytosol]
adenylatedG304-UBC(229-304) [cytosol]
adenylatedG684-UBC(609-684) [cytosol]
adenylatedG152-UBC(77-152) [cytosol]
adenylatedG532-UBC(457-532) [cytosol]
adenylatedG228-UBC(153-228) [cytosol]
adenylatedG456-UBC(381-456) [cytosol]
Ub-428-UBC(381-456) [endoplasmic reticulum membrane]
Ub-656-UBC(609-684) [endoplasmic reticulum membrane]
Ub-124-UBC(77-152) [endoplasmic reticulum membrane]
Ub-48-UBC(1-76) [endoplasmic reticulum membrane]
Ub-352-UBC(305-380) [endoplasmic reticulum membrane]
Ub-504-UBC(457-532) [endoplasmic reticulum membrane]
Ub-276-UBC(229-304) [endoplasmic reticulum membrane]
Ub-580-UBC(533-608) [endoplasmic reticulum membrane]
Ub-200-UBC(153-228) [endoplasmic reticulum membrane]
Ub-428-UBC(381-456) [lysosomal membrane]
Ub-352-UBC(305-380) [lysosomal membrane]
Ub-656-UBC(609-684) [lysosomal membrane]
Ub-124-UBC(77-152) [lysosomal membrane]
Ub-504-UBC(457-532) [lysosomal membrane]
Ub-580-UBC(533-608) [lysosomal membrane]
Ub-48-UBC(1-76) [lysosomal membrane]
Ub-200-UBC(153-228) [lysosomal membrane]
Ub-276-UBC(229-304) [lysosomal membrane]
Ub-48-UBC(1-76) [endocytic vesicle membrane]
Ub-352-UBC(305-380) [endocytic vesicle membrane]
Ub-276-UBC(229-304) [endocytic vesicle membrane]
Ub-428-UBC(381-456) [endocytic vesicle membrane]
Ub-504-UBC(457-532) [endocytic vesicle membrane]
Ub-200-UBC(153-228) [endocytic vesicle membrane]
Ub-580-UBC(533-608) [endocytic vesicle membrane]
Ub-124-UBC(77-152) [endocytic vesicle membrane]
Ub-656-UBC(609-684) [endocytic vesicle membrane]
UBC(1-76) [endosome membrane]
UBC(533-608) [endosome membrane]
UBC(77-152) [endosome membrane]
UBC(305-380) [endosome membrane]
UBC(457-532) [endosome membrane]
UBC(381-456) [endosome membrane]
UBC(153-228) [endosome membrane]
UBC(609-684) [endosome membrane]
UBC(229-304) [endosome membrane]
UBC(1-76) [plasma membrane]
UBC(457-532) [plasma membrane]
UBC(153-228) [plasma membrane]
UBC(609-684) [plasma membrane]
UBC(77-152) [plasma membrane]
UBC(229-304) [plasma membrane]
UBC(533-608) [plasma membrane]
UBC(381-456) [plasma membrane]
UBC(305-380) [plasma membrane]
Ub-29-UBC(1-76) [cytosol]
Ub-257-UBC(229-304) [cytosol]
Ub-333-UBC(305-380) [cytosol]
Ub-409-UBC(381-456) [cytosol]
Ub-485-UBC(457-532) [cytosol]
Ub-561-UBC(533-608) [cytosol]
Ub-105-UBC(77-152) [cytosol]
Ub-181-UBC(153-228) [cytosol]
Ub-637-UBC(609-684) [cytosol]
Ub-310-UBC(305-380) [cytosol]
Ub-6-UBC(1-76) [cytosol]
Ub-462-UBC(457-532) [cytosol]
Ub-386-UBC(381-456) [cytosol]
Ub-538-UBC(533-608) [cytosol]
Ub-158-UBC(153-228) [cytosol]
Ub-614-UBC(609-684) [cytosol]
Ub-234-UBC(229-304) [cytosol]
Ub-82-UBC(77-152) [cytosol]
Ub-255-UBC(229-304) [cytosol]
Ub-179-UBC(153-228) [cytosol]
Ub-103-UBC(77-152) [cytosol]
Ub-483-UBC(457-532) [cytosol]
Ub-559-UBC(533-608) [cytosol]
Ub-635-UBC(609-684) [cytosol]
Ub-331-UBC(305-380) [cytosol]
Ub-27-UBC(1-76) [cytosol]
Ub-407-UBC(381-456) [cytosol]
Ub-109-UBC(77-152) [cytosol]
Ub-33-UBC(1-76) [cytosol]
Ub-489-UBC(457-532) [cytosol]
Ub-337-UBC(305-380) [cytosol]
Ub-641-UBC(609-684) [cytosol]
Ub-413-UBC(381-456) [cytosol]
Ub-261-UBC(229-304) [cytosol]
Ub-565-UBC(533-608) [cytosol]
Ub-185-UBC(153-228) [cytosol]
M1-UBC(533-608) [cytosol]
M1-UBC(1-76) [cytosol]
M1-UBC(457-532) [cytosol]
M1-UBC(381-456) [cytosol]
M1-UBC(305-380) [cytosol]
M1-UBC(229-304) [cytosol]
M1-UBC(77-152) [cytosol]
M1-UBC(609-684) [cytosol]
M1-UBC(153-228) [cytosol]
UBC(77-152) [endoplasmic reticulum membrane]
UBC(381-456) [endoplasmic reticulum membrane]
UBC(533-608) [endoplasmic reticulum membrane]
UBC(609-684) [endoplasmic reticulum membrane]
UBC(229-304) [endoplasmic reticulum membrane]
UBC(153-228) [endoplasmic reticulum membrane]
UBC(1-76) [endoplasmic reticulum membrane]
UBC(305-380) [endoplasmic reticulum membrane]
UBC(457-532) [endoplasmic reticulum membrane]
Ub-407-UBC(381-456) [nucleoplasm]
Ub-483-UBC(457-532) [nucleoplasm]
Ub-103-UBC(77-152) [nucleoplasm]
Ub-255-UBC(229-304) [nucleoplasm]
Ub-179-UBC(153-228) [nucleoplasm]
Ub-559-UBC(533-608) [nucleoplasm]
Ub-27-UBC(1-76) [nucleoplasm]
Ub-635-UBC(609-684) [nucleoplasm]
Ub-331-UBC(305-380) [nucleoplasm]
Ub-637-UBC(609-684) [nucleoplasm]
Ub-257-UBC(229-304) [nucleoplasm]
Ub-561-UBC(533-608) [nucleoplasm]
Ub-409-UBC(381-456) [nucleoplasm]
Ub-181-UBC(153-228) [nucleoplasm]
Ub-105-UBC(77-152) [nucleoplasm]
Ub-333-UBC(305-380) [nucleoplasm]
Ub-29-UBC(1-76) [nucleoplasm]
Ub-485-UBC(457-532) [nucleoplasm]
Ub-185-UBC(153-228) [nucleoplasm]
Ub-337-UBC(305-380) [nucleoplasm]
Ub-33-UBC(1-76) [nucleoplasm]
Ub-109-UBC(77-152) [nucleoplasm]
Ub-261-UBC(229-304) [nucleoplasm]
Ub-641-UBC(609-684) [nucleoplasm]
Ub-565-UBC(533-608) [nucleoplasm]
Ub-413-UBC(381-456) [nucleoplasm]
Ub-489-UBC(457-532) [nucleoplasm]
Ub-467-UBC(457-532) [nucleoplasm]
Ub-163-UBC(153-228) [nucleoplasm]
Ub-11-UBC(1-76) [nucleoplasm]
Ub-87-UBC(77-152) [nucleoplasm]
Ub-239-UBC(229-304) [nucleoplasm]
Ub-543-UBC(533-608) [nucleoplasm]
Ub-391-UBC(381-456) [nucleoplasm]
Ub-315-UBC(305-380) [nucleoplasm]
Ub-619-UBC(609-684) [nucleoplasm]
Ub-519-UBC(457-532) [endosome membrane]
Ub-367-UBC(305-380) [endosome membrane]
Ub-291-UBC(229-304) [endosome membrane]
Ub-443-UBC(381-456) [endosome membrane]
Ub-215-UBC(153-228) [endosome membrane]
Ub-63-UBC(1-76) [endosome membrane]
Ub-595-UBC(533-608) [endosome membrane]
Ub-139-UBC(77-152) [endosome membrane]
Ub-671-UBC(609-684) [endosome membrane]
Ub-291-UBC(229-304) [plasma membrane]
Ub-595-UBC(533-608) [plasma membrane]
Ub-367-UBC(305-380) [plasma membrane]
Ub-63-UBC(1-76) [plasma membrane]
Ub-139-UBC(77-152) [plasma membrane]
Ub-215-UBC(153-228) [plasma membrane]
Ub-519-UBC(457-532) [plasma membrane]
Ub-671-UBC(609-684) [plasma membrane]
Ub-443-UBC(381-456) [plasma membrane]
Ub-87-UBC(77-152) [cytosol]
Ub-163-UBC(153-228) [cytosol]
Ub-619-UBC(609-684) [cytosol]
Ub-467-UBC(457-532) [cytosol]
Ub-11-UBC(1-76) [cytosol]
Ub-543-UBC(533-608) [cytosol]
Ub-391-UBC(381-456) [cytosol]
Ub-315-UBC(305-380) [cytosol]
Ub-239-UBC(229-304) [cytosol]
UBC(229-304) [nucleoplasm]
UBC(381-456) [nucleoplasm]
UBC(305-380) [nucleoplasm]
UBC(457-532) [nucleoplasm]
UBC(533-608) [nucleoplasm]
UBC(77-152) [nucleoplasm]
UBC(609-684) [nucleoplasm]
UBC(1-76) [nucleoplasm]
UBC(153-228) [nucleoplasm]
Ub-124-UBC(77-152) [nucleoplasm]
Ub-580-UBC(533-608) [nucleoplasm]
Ub-428-UBC(381-456) [nucleoplasm]
Ub-276-UBC(229-304) [nucleoplasm]
Ub-352-UBC(305-380) [nucleoplasm]
Ub-200-UBC(153-228) [nucleoplasm]
Ub-48-UBC(1-76) [nucleoplasm]
Ub-656-UBC(609-684) [nucleoplasm]
Ub-504-UBC(457-532) [nucleoplasm]
Ub-671-UBC(609-684) [nucleoplasm]
Ub-215-UBC(153-228) [nucleoplasm]
Ub-63-UBC(1-76) [nucleoplasm]
Ub-443-UBC(381-456) [nucleoplasm]
Ub-367-UBC(305-380) [nucleoplasm]
Ub-139-UBC(77-152) [nucleoplasm]
Ub-519-UBC(457-532) [nucleoplasm]
Ub-595-UBC(533-608) [nucleoplasm]
Ub-291-UBC(229-304) [nucleoplasm]
Ub-82-UBC(77-152) [nucleoplasm]
Ub-6-UBC(1-76) [nucleoplasm]
Ub-234-UBC(229-304) [nucleoplasm]
Ub-158-UBC(153-228) [nucleoplasm]
Ub-310-UBC(305-380) [nucleoplasm]
Ub-538-UBC(533-608) [nucleoplasm]
Ub-462-UBC(457-532) [nucleoplasm]
Ub-386-UBC(381-456) [nucleoplasm]
Ub-614-UBC(609-684) [nucleoplasm]
UBC(609-684) [late endosome lumen]
UBC(153-228) [late endosome lumen]
UBC(305-380) [late endosome lumen]
UBC(77-152) [late endosome lumen]
UBC(533-608) [late endosome lumen]
UBC(229-304) [late endosome lumen]
UBC(457-532) [late endosome lumen]
UBC(381-456) [late endosome lumen]
UBC(1-76) [late endosome lumen]
UBC(153-228) [mitochondrial outer membrane]
UBC(305-380) [mitochondrial outer membrane]
UBC(77-152) [mitochondrial outer membrane]
UBC(229-304) [mitochondrial outer membrane]
UBC(381-456) [mitochondrial outer membrane]
UBC(609-684) [mitochondrial outer membrane]
UBC(1-76) [mitochondrial outer membrane]
UBC(457-532) [mitochondrial outer membrane]
UBC(533-608) [mitochondrial outer membrane]
Ub-48-UBC(1-76) [cytosol]
Ub-656-UBC(609-684) [cytosol]
Ub-428-UBC(381-456) [cytosol]
Ub-504-UBC(457-532) [cytosol]
Ub-580-UBC(533-608) [cytosol]
Ub-276-UBC(229-304) [cytosol]
Ub-124-UBC(77-152) [cytosol]
Ub-200-UBC(153-228) [cytosol]
Ub-352-UBC(305-380) [cytosol]
p-S141-UBC(77-152) [mitochondrial outer membrane]
p-S597-UBC(533-608) [cytosol]
p-S369-UBC(305-380) [mitochondrial outer membrane]
p-S293-UBC(229-304) [mitochondrial outer membrane]
p-S521-UBC(457-532) [mitochondrial outer membrane]
p-S445-UBC(381-456) [mitochondrial outer membrane]
p-S673-UBC(609-684) [mitochondrial outer membrane]
p-S65-UBC(1-76) [mitochondrial outer membrane]
p-S217-UBC(153-228) [mitochondrial outer membrane]
UBC(457-532) [cytosol]
UBC(1-76) [cytosol]
UBC(229-304) [cytosol]
UBC(153-228) [cytosol]
UBC(609-684) [cytosol]
UBC(77-152) [cytosol]
UBC(305-380) [cytosol]
UBC(533-608) [cytosol]
UBC(1-76) [lysosomal lumen]
UBC(305-380) [lysosomal lumen]
UBC(77-152) [lysosomal lumen]
UBC(609-684) [lysosomal lumen]
UBC(153-228) [lysosomal lumen]
UBC(457-532) [lysosomal lumen]
UBC(381-456) [lysosomal lumen]
UBC(229-304) [lysosomal lumen]
UBC(533-608) [lysosomal lumen]
Ub-215-UBC(153-228) [cytosol]
Ub-139-UBC(77-152) [cytosol]
Ub-595-UBC(533-608) [cytosol]
Ub-291-UBC(229-304) [cytosol]
Ub-367-UBC(305-380) [cytosol]
Ub-671-UBC(609-684) [cytosol]
Ub-63-UBC(1-76) [cytosol]
Ub-519-UBC(457-532) [cytosol]
Ub-443-UBC(381-456) [cytosol]
Inferred To
UBI-P63E 6 [cytosol]
(Drosophila melanogaster)
ubqJ [cytosol]
(Dictyostelium discoideum)
ubqI [cytosol]
(Dictyostelium discoideum)
ubc [cytosol]
(Xenopus tropicalis)
Ubc [cytosol]
(Rattus norvegicus)
ubq-1 [cytosol]
(Caenorhabditis elegans)
ubqH [cytosol]
(Dictyostelium discoideum)
Homologues of UBC(381-456) [cytosol]
(Dictyostelium discoideum)
Homologues of UBC(381-456) [cytosol]
(Sus scrofa)
Ubb [cytosol]
(Mus musculus)
ubqG [cytosol]
(Dictyostelium discoideum)
UBC(381-456) [cytosol]
(Plasmodium falciparum)
UBC [cytosol]
(Bos taurus)
UBC [cytosol]
(Canis familiaris)
UBC [cytosol]
(Sus scrofa)
UBB [cytosol]
(Gallus gallus)
UBB [cytosol]
(Sus scrofa)
ubqF [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_066289.3
OpenTargets
ENSG00000150991
GeneCards
P0CG48
HPA
ENSG00000150991-UBC
Ensembl
ENSP00000441543
,
ENST00000536769
,
ENSP00000344818
,
ENSG00000150991
,
ENST00000339647
PRO
P0CG48
Pharos - Targets
P0CG48
PDB
6P5B
,
6V5D
,
4LCD
,
4UN2
,
3VUW
,
2KDF
,
2K8B
,
2DEN
,
6N6R
,
6OI4
,
2N2K
,
7EAO
,
4KSK
,
2MBQ
,
4WZP
,
4NQK
,
3AUL
,
1YX6
,
3O65
,
7K6Q
,
6TXB
,
8E7O
,
1XD3
,
3B0A
,
5AF6
,
1XQQ
,
2JZZ
,
4DDG
,
4BOS
,
5AF5
,
3VUX
,
8ST8
,
8A9K
,
6WKR
,
4AP4
,
7M4N
,
5A5B
,
7M4O
,
2KLG
,
5C7M
,
6B7O
,
5WQ4
,
2IBI
,
2PEA
,
4K7S
,
6VAF
,
3C0R
,
4MM3
,
1Q5W
,
3PT2
,
6NQA
,
5UDH
,
3ZNZ
,
6VEN
,
1FXT
,
2FUH
,
7K6P
,
3VFK
,
3UGB
,
2L3Z
,
6SQR
,
2ZVO
,
2HTH
,
2NR2
,
5ZQ6
,
2MRE
,
2GBM
,
3HM3
,
3V6E
,
5NMC
,
7R70
,
3PTF
,
2MCN
,
2KX0
,
2J7Q
,
3B08
,
1SIF
,
2GBN
,
7JXV
,
3EHV
,
2MBO
,
2KJH
,
2MOR
,
4K7U
,
3MTN
,
7TV4
,
3MHS
,
2JRI
,
5B83
,
3N3K
,
2GMI
,
3IFW
,
3RUL
,
8PMQ
,
2LD9
,
3OFI
,
6N13
,
2GBK
,
6TNF
,
1D3Z
,
5E6J
,
8B3I
,
2GBJ
,
5ZQ7
,
2LVQ
,
2RU6
,
8EB0
,
2LVO
,
8A9J
,
2K6D
,
7M4M
,
3BY4
,
3V6C
,
3H7S
,
3Q3F
,
1NBF
,
6VAE
,
4DHZ
,
2G45
,
7NPI
,
1S1Q
,
6T9L
,
7BXG
,
6WJD
,
5C7J
,
3LDZ
,
6B7M
,
7MYF
,
7UV5
,
3ONS
,
4ZQS
,
3I3T
,
3WXF
,
8PJN
,
8ADB
,
4BOZ
,
1TBE
,
2Y5B
,
4V3L
,
3NS8
,
5AIU
,
2LVP
,
3JSV
,
7ZJ3
,
8FTQ
,
5ZQ5
,
3ZNH
,
1F9J
,
1G6J
,
6RYA
,
5OXH
,
5ZQ4
,
2JF5
,
2ZVN
,
3A33
,
6W9S
,
4AUQ
,
8AMS
,
3PRM
,
2WDT
,
6UPU
,
4IG7
,
6TUV
,
3N32
,
2XEW
,
3ALB
,
4DHJ
,
2Z59
,
6A43
,
2ZCB
,
2MWS
,
8R5H
,
8Q7R
,
7EB9
,
1UBI
,
4MSQ
,
8RX0
,
6UMP
,
1UD7
,
6TTU
,
5AIT
,
2W9N
,
3KW5
,
5OXI
,
3H7P
,
6UMS
,
3K9O
,
3EFU
,
1C3T
,
2PE9
,
3ZLZ
,
3K9P
,
3KVF
,
3ZNI
,
4IUM
,
2BGF
,
5ZQ3
,
2K8C
,
4FJV
,
4LDT
,
6A44
,
3DVN
,
2RR9
,
4HXD
,
7MIC
,
6S53
,
5OHV
,
3N30
,
4V3K
,
6W9D
,
1CMX
,
3U30
,
4XOL
,
8EAZ
,
4XOK
,
2MI8
,
2OJR
,
7B5N
,
2AYO
,
6W9R
,
6T7F
,
4HK2
,
3EEC
,
8T48
,
4BVU
,
1UBQ
,
6QML
,
4K1R
,
7BBF
,
4MDK
,
7YUI
,
2KN5
,
6WTG
,
8ST9
,
8SVF
,
4I6N
,
2KHW
,
8OFF
,
2LZ6
,
5H07
,
1OGW
,
3DVG
,
2K25
,
4I6L
,
6Z7V
,
7MEX
,
7B5L
,
6AQR
,
4MSM
,
5OE7
,
3WXE
,
4JQW
,
6NXK
,
3TMP
,
4K7W
,
3VUY
,
8ST7
,
2MJ5
,
7BBD
,
6K2U
,
7EAL
,
3IHP
,
7UYH
,
1ZGU
,
8PQL
,
3JW0
,
4KSL
,
5NLI
,
6EQI
,
5NLF
,
7OWD
,
6Q00
,
2JY6
,
1YX5
,
3OJ3
,
4DDI
,
7B5M
,
6KBE
,
5NL4
,
3OJ4
,
3JVZ
,
2GBR
,
5AF4
,
6ULH
,
1GJZ
,
7KEO
,
2O6V
Interactors (76)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.96
15
UniProt:P55036 PSMD4
1
PSMD4 [cytosol]
(R-HSA-68800)
0.851
7
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.84
8
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.821
6
UniProt:Q13501 SQSTM1
7
SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711967)
SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711954)
K7 ub-SQSTM1 [cytosol]
(R-HSA-9759088)
p-S349 SQSTM1 [cytosol]
(R-HSA-9766524)
ub K420 p-S349 SQSTM1 [cytosol]
(R-HSA-9766536)
SQSTM1 [nucleoplasm]
(R-HSA-210961)
SQSTM1 [cytosol]
(R-HSA-193937)
0.806
5
UniProt:Q04206 RELA
7
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.77
6
UniProt:Q92783 STAM
1
STAM [cytosol]
(R-HSA-182925)
0.766
6
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.75
4
UniProt:P40343 VPS27
0.715
5
UniProt:Q86VP1 TAX1BP1
1
TAX1BP1 [cytosol]
(R-HSA-937346)
0.715
8
UniProt:P54252-1 ATXN3
0.704
4
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.702
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.688
5
UniProt:P54727 RAD23B
2
RAD23B [nucleoplasm]
(R-HSA-62590)
RAD23B [cytosol]
(R-HSA-8850589)
0.683
5
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [plasma membrane]
(R-HSA-182955)
SH3KBP1 [cytosol]
(R-HSA-182957)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.683
6
UniProt:Q9Y253 POLH
2
MonoUb-K682,K686,K694,K709-POLH [nucleoplasm]
(R-HSA-5655163)
POLH [nucleoplasm]
(R-HSA-110287)
0.658
4
UniProt:O43583 DENR
0.656
3
UniProt:P25963 NFKBIA
9
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
0.656
3
UniProt:O43318 MAP3K7
10
PolyUb-MAP3K7 [cytosol]
(R-HSA-6782968)
MAP3K7 [plasma membrane]
(R-HSA-9012677)
K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]
(R-HSA-5607649)
K63polyUb-34,158-TAK1 [cytosol]
(R-HSA-5607643)
p-MAP3K7 [cytosol]
(R-HSA-168163)
p-T187-MAP3K7 [cytosol]
(R-HSA-206014)
MAP3K7 [endosome membrane]
(R-HSA-450315)
p-T184,T187-MAP3K7 [endosome membrane]
(R-HSA-450332)
MAP3K7 [cytosol]
(R-HSA-168156)
p-T184,T187-MAP3K7 [cytosol]
(R-HSA-202527)
0.656
4
UniProt:Q14596 NBR1
2
NBR1 [peroxisomal membrane]
(R-HSA-9665177)
NBR1 [cytosol]
(R-HSA-9665180)
0.636
3
UniProt:Q16186 ADRM1
2
ADRM1 [nucleoplasm]
(R-HSA-9918361)
ADRM1 [cytosol]
(R-HSA-5665939)
0.609
11
UniProt:Q8N488 RYBP
1
RYBP [nucleoplasm]
(R-HSA-8937975)
0.602
3
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.602
3
UniProt:Q9UBN7 HDAC6
4
HDAC6 [nucleoplasm]
(R-HSA-351589)
HDAC6 [late endosome lumen]
(R-HSA-9659980)
HDAC6 [cytosol]
(R-HSA-5324660)
HDAC6 [lysosomal lumen]
(R-HSA-9660002)
0.593
3
UniProt:Q99PZ6 OSPG
0.591
3
UniProt:Q14934 NFAC4
0.591
3
UniProt:Q8TAT6 NPLOC4
2
NPLOC4 [nucleoplasm]
(R-HSA-5654987)
NPLOC4 [cytosol]
(R-HSA-9755492)
0.59
2
UniProt:P35226 BMI1
3
BMI1 [nucleoplasm]
(R-HSA-389121)
p-S-BMI1 [nucleoplasm]
(R-HSA-3229116)
monoSUMO1-K88-BMI1 [nucleoplasm]
(R-HSA-4551729)
0.589
2
UniProt:Q9UER7 DAXX
13
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX [nucleoplasm]
(R-HSA-3222068)
0.573
2
UniProt:P0DTD1-PRO_0000449621 REP
0.558
2
UniProt:P0C6X7-PRO_0000037311 REP
0.558
3
ChEBI:167176 GRL-0617
0.558
4
UniProt:Q64339
3
Isg15 [nucleoplasm]
(R-MMU-5653665)
Isg15 [nucleoplasm]
(R-MMU-5653745)
Isg15 [cytosol]
(R-MMU-936552)
0.558
2
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.558
2
UniProt:Q05086-3 UBE3A
0.556
3
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
UniProt:Q9NRQ2 PLS4
0.556
3
UniProt:Q96CS7 PKHB2
0.556
3
UniProt:Q15038 DAZP2
0.556
6
UniProt:P60604 UBE2G2
2
Ub-C89-UBE2G2 [cytosol]
(R-HSA-8864195)
UBE2G2 [cytosol]
(R-HSA-947640)
0.556
3
UniProt:Q92567-2 FAM168A
0.556
3
UniProt:Q8N3F0 MTURN
0.556
3
UniProt:Q9BSL1 UBAC1
1
UBAC1 [cytosol]
(R-HSA-8851644)
0.556
3
UniProt:O95208-2 EPN2
0.556
3
UniProt:Q9H305 CDIP1
0.556
3
UniProt:Q5VVQ6 YOD1
1
YOD1 [cytosol]
(R-HSA-6781909)
0.556
3
UniProt:Q6ICB0 DESI1
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P05412 JUN
4
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
0.547
2
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.547
2
UniProt:O76080 ZFAN5
0.544
3
UniProt:Q62921
1
RBCK1 [cytosol]
(R-RNO-976018)
0.544
2
UniProt:Q12518
1
ENT1 [cytosol]
(R-SCE-8865826-2)
0.544
3
UniProt:P06239 LCK
4
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [cytosol]
(R-HSA-202308)
LCK [cytosol]
(R-HSA-167609)
0.544
2
UniProt:Q9Z2V5 Hdac6
3
HDAC6 [nucleoplasm]
(R-MMU-351589)
Hdac6 [cytosol]
(R-MMU-9646357)
HDAC6 [cytosol]
(R-MMU-5324660)
0.544
2
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.544
2
UniProt:Q9UNA4 POLI
1
POLI [nucleoplasm]
(R-HSA-5656133)
0.527
4
UniProt:Q8IXI1 RHOT2
1
RHOT2 [mitochondrial outer membrane]
(R-HSA-3006730)
0.527
2
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
NEDD8(77-81) [cytosol]
(R-HSA-6782654)
NEDD8(1-81) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8 [cytosol]
(R-HSA-416969)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.527
2
UniProt:Q9NX47 MARH5
0.524
2
UniProt:Q9H4L4 SENP3
1
SENP3 [nucleoplasm]
(R-HSA-2984296)
0.524
2
UniProt:Q9ULH1 ASAP1
1
ASAP1 [cytosol]
(R-HSA-5620905)
0.524
2
UniProt:P48357-3 LEPR
0.524
2
UniProt:Q9Y6R4 M3K4
0.524
2
UniProt:O43150 ASAP2
0.524
2
UniProt:Q9HB09-1 BCL2L12
0.524
3
UniProt:P04325 REV
0.524
2
UniProt:P09874 PARP1
4
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
PARP1 [nucleoplasm]
(R-HSA-201568)
0.524
2
UniProt:Q13887 KLF5
1
KLF5 [nucleoplasm]
(R-HSA-381279)
0.524
2
UniProt:P37840 SNCA
5
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
Ub-SNCA [cytosol]
(R-HSA-5660754)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
SNCA [cytosol]
(R-HSA-5658500)
0.524
2
UniProt:Q99062 CSF3R
5
K48polyUb-K655,p-4Y-CSF3R [lysosomal membrane]
(R-HSA-9707928)
CSF3R [plasma membrane]
(R-HSA-6787734)
p-4Y-CSF3R [plasma membrane]
(R-HSA-9674543)
p-4Y-CSF3R [endocytic vesicle membrane]
(R-HSA-9705736)
K48polyUb-K655,p-4Y-CSF3R [endocytic vesicle membrane]
(R-HSA-9705727)
0.524
2
UniProt:P25098 GRK2
4
p-S29-ADRBK1 [cytosol]
(R-HSA-9645318)
ADRBK1 [cilium]
(R-HSA-5632504)
p-S29-ADRBK1 [plasma membrane]
(R-HSA-111969)
GRK2 [plasma membrane]
(R-HSA-50270)
0.524
3
UniProt:Q9UDY8 MALT1
1
MALT1 [cytosol]
(R-HSA-202461)
0.524
4
UniProt:Q9Y5X1 SNX9
3
SNX9 [cytosol]
(R-HSA-8867737)
SNX9 [Golgi membrane]
(R-HSA-432988)
SNX9 [cytoplasmic vesicle membrane]
(R-HSA-432990)
0.499
2
UniProt:P35227 PCGF2
1
PCGF2 [nucleoplasm]
(R-HSA-389115)
0.499
2
UniProt:P09429 HMGB1
5
HMGB1 [secretory granule lumen]
(R-HSA-6803337)
HMGB1 [ficolin-1-rich granule lumen]
(R-HSA-6803291)
HMGB1 [extracellular region]
(R-HSA-879382)
HMGB1 [nucleoplasm]
(R-HSA-266221)
HC23,45-HMGB1 [extracellular region]
(R-HSA-6797422)
0.482
2
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