P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane

Stable Identifier
R-HSA-939763
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Synonyms
P-type ATPase type IV subfamily transporters may mediate phospholipid transfer
ReviewStatus
5/5
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P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane
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The plasma membrane contains a broad range of lipids making up the bilayer. Aminophospholipids such as phosphatidylserine (PS) and phosphatidylethanolamine (PE) are distributed in this bilayer and their arrangement is mediated by the P-type ATPases type IV family (Paulusma and Oude Elferink, 2005).
Literature References
PubMed ID Title Journal Year
15919184 The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease

Paulusma, CC, Oude Elferink, RP

Biochim Biophys Acta 2005
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Output
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as an event of
Event Information
Reverse Reaction
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Homo sapiens)
Catalyst Activity

ATPase-coupled intramembrane lipid transporter activity of P-type ATPases type IV [plasma membrane]

Physical Entity
P-type ATPases type IV [plasma membrane] (Homo sapiens)
Activity
ATPase-coupled intramembrane lipid transporter activity (GO:0140326)
Orthologous Events
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Bos taurus)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Caenorhabditis elegans)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Canis familiaris)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Danio rerio)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Dictyostelium discoideum)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Drosophila melanogaster)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Gallus gallus)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Mus musculus)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Plasmodium falciparum)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Rattus norvegicus)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Saccharomyces cerevisiae)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Schizosaccharomyces pombe)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Sus scrofa)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Xenopus tropicalis)
Authored
Jassal, B  (2010-09-01)
Reviewed
He, L  (2010-11-15)
Created
Jassal, B  (2010-09-01)
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