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RGS17 [plasma membrane]
Stable Identifier
R-HSA-939779
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Regulator of G-protein signaling 17, RGS17_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Active G alpha (i)–i1/i2/i3 binds RGS proteins (Homo sapiens)
G alpha (i):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS17 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS17 [plasma membrane] (Homo sapiens)
G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Homo sapiens)
G alpha (i):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS17 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS17 [plasma membrane] (Homo sapiens)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Homo sapiens)
G alpha (i):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS17 [plasma membrane] (Homo sapiens)
G alpha (i):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS17 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS17 [plasma membrane] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Active G alpha (q) binds RGS proteins (Homo sapiens)
G alpha (q):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS17 [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS17 [plasma membrane] (Homo sapiens)
G alpha (q) in G (q):RGS complex is inactivated (Homo sapiens)
G alpha (q):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS17 [plasma membrane] (Homo sapiens)
G alpha (q):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS17 [plasma membrane] (Homo sapiens)
G alpha (q):RGS dissociates to inactive G alpha (q) (Homo sapiens)
G alpha (q):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS17 [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS17 [plasma membrane] (Homo sapiens)
G alpha (z) signalling events (Homo sapiens)
Active G alpha (z) binds RGS proteins (Homo sapiens)
G alpha (z):GTP:RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS17 [plasma membrane] (Homo sapiens)
RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS17 [plasma membrane] (Homo sapiens)
G alpha (z) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
RGS proteins active for G alpha (z) [plasma membrane] (Homo sapiens)
RGS17 [plasma membrane] (Homo sapiens)
G alpha (z) in G alpha (z):RGS complex is inactivated (Homo sapiens)
G alpha (z):GDP:RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS17 [plasma membrane] (Homo sapiens)
G alpha (z):GTP:RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS17 [plasma membrane] (Homo sapiens)
RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS17 [plasma membrane] (Homo sapiens)
G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Homo sapiens)
G alpha (z):GDP:RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS17 [plasma membrane] (Homo sapiens)
RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS17 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UGC6 RGS17
Gene Names
RGS17, RGSZ2
Chain
chain:1-210
Reference Genes
BioGPS Gene:26575 RGS17
COSMIC (genes):RGS17 RGS17
CTD Gene:26575 RGS17
dbSNP Gene:26575 RGS17
ENSEMBL:ENSG00000091844 RGS17
ENSEMBL_homo_sapiens_GENE:ENSG00000091844.8 RGS17
HGNC:14088 RGS17
KEGG Gene (Homo sapiens):26575 RGS17
Monarch:26575 RGS17
NCBI Gene:26575 RGS17
OMIM:607191 RGS17
UCSC:Q9UGC6 RGS17
Reference Transcript
RefSeq:NM_012419.4 RGS17
Other Identifiers
11740078_at
17025005
215560_3p_x_at
215560_PM_x_at
215560_x_at
217204_PM_at
217204_at
220334_PM_at
220334_at
26575
2755714
2755715
2980273
2980274
2980275
2980276
2980277
2980278
2980279
2980280
2980281
2980282
2980283
2980284
2980286
2980288
2980289
2980291
2980292
2980293
2980300
2980302
2980303
2980312
2980313
2980314
2980321
3349612
34123_at
3511104
69806_at
8098705
8130394
A_23_P156861
GE81796
GO:0001975
GO:0003824
GO:0003924
GO:0005096
GO:0005515
GO:0005634
GO:0005737
GO:0005886
GO:0007186
GO:0009968
GO:0016020
GO:0016787
GO:0023052
GO:0043005
GO:0043226
GO:0045202
GO:0098772
HMNXSV003034044
HMNXSV003045649
HMNXSV003053484
Hs.225836.0.S1_3p_at
Hs.274266.0.S1_3p_at
Hs.274266.0.S1_3p_x_at
ILMN_1725485
PH_hs_0013740
TC06002242.hg
g8394185_3p_at
Participates
as a member of
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS16,17,20 [plasma membrane] (Homo sapiens)
RGS proteins active for G alpha (z) [plasma membrane] (Homo sapiens)
Inferred To
Rgs17 [plasma membrane]
(Mus musculus)
Rgs17 [plasma membrane]
(Rattus norvegicus)
rgs-1 [plasma membrane]
(Caenorhabditis elegans)
rgs17 [plasma membrane]
(Xenopus tropicalis)
SST2 [plasma membrane]
(Saccharomyces cerevisiae)
Homologues of RGS17 [plasma membrane]
(Caenorhabditis elegans)
Homologues of RGS17 [plasma membrane]
(Dictyostelium discoideum)
Homologues of RGS17 [plasma membrane]
(Saccharomyces cerevisiae)
rgs-2 [plasma membrane]
(Caenorhabditis elegans)
Dhit [plasma membrane]
(Drosophila melanogaster)
RGS2 [plasma membrane]
(Saccharomyces cerevisiae)
rgs1 [plasma membrane]
(Schizosaccharomyces pombe)
RGS17 [plasma membrane]
(Bos taurus)
RGS17 [plasma membrane]
(Canis familiaris)
RGS17 [plasma membrane]
(Dictyostelium discoideum)
RGS17 [plasma membrane]
(Gallus gallus)
RGS17 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_036551.3
Guide to Pharmacology - Targets
2801
OpenTargets
ENSG00000091844
HPA
ENSG00000091844-RGS17
GeneCards
Q9UGC6
Ensembl
ENST00000206262
,
ENST00000367225
,
ENSG00000091844
,
ENSP00000356194
,
ENSP00000206262
PRO
Q9UGC6
Pharos - Targets
Q9UGC6
PDB
6AM3
,
1ZV4
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.718
6
UniProt:Q92504 SLC39A7
1
SLC39A7 [endoplasmic reticulum membrane]
(R-HSA-442363)
0.556
3
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.556
3
UniProt:Q9H2F3 HSD3B7
1
HSD3B7 [endoplasmic reticulum membrane]
(R-HSA-193441)
0.556
3
UniProt:Q53GS7 GLE1
1
GLE1 [nucleoplasm]
(R-HSA-8932905)
0.556
3
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