Reactome | UBA3 [cytosol]

UBA3 [cytosol]

Stable Identifier

R-HSA-947632

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NEDD8-activating enzyme E1 catalytic subunit, UBA3_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q13564 NAE1

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External Reference Information

External Reference

UniProt:Q8TBC4 UBA3

Gene Names

UBA3, UBE1C

Chain

initiator methionine:, chain:2-463

Reference Genes

BioGPS Gene:9039 UBA3

COSMIC (genes):UBA3 UBA3

CTD Gene:9039 UBA3

dbSNP Gene:9039 UBA3

ENSEMBL:ENSG00000144744 UBA3

HGNC:12470 UBA3

KEGG:hsa:9039 UBA3

Monarch:9039 UBA3

NCBI Gene:9039 UBA3

OMIM:603172 UBA3

UCSC:Q8TBC4 UBA3

Reference Transcript

Other Identifiers

11730728_a_at

16956055

209115_PM_at

209115_at

2681196

2681197

2681198

2681199

2681200

2681201

2681203

2681205

2681207

2681208

2681210

2681212

2681214

2681215

2681216

2681217

2681218

2681219

2681221

2681223

2681224

2681225

2681226

2681227

2681228

2681229

2681230

2681232

2681233

2681234

2681235

2681238

40066_at

8088718

9039

A_23_P211840

GE54399

GO:0000278

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0006508

GO:0007113

GO:0008641

GO:0016740

GO:0016874

GO:0019781

GO:0019788

GO:0032991

GO:0036211

GO:0042802

GO:0043226

GO:0043687

GO:0045116

GO:0046982

GO:0051726

GO:0140096

GO:0140657

HMNXSV003011768

ILMN_1689142

ILMN_2324157

PH_hs_0029245

TC03001538.hg

g5912116_3p_at

Participates

as a component of

UBA3:NAE1 [cytosol] (Homo sapiens)

as an output of

SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)

as an input of

SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)

as a candidate of

Ubiquitin activating E1 enzymes [cytosol] (Homo sapiens)

Other forms of this molecule

G76-NEDD8-C237-UBA3 [cytosol]

Inferred To

UBA3 [cytosol] (Bos taurus)

UBA3 [cytosol] (Caenorhabditis elegans)

UBA3 [cytosol] (Canis familiaris)

UBA3 [cytosol] (Danio rerio)

UBA3 [cytosol] (Dictyostelium discoideum)

UBA3 [cytosol] (Drosophila melanogaster)

UBA3 [cytosol] (Gallus gallus)

UBA3 [cytosol] (Mus musculus)

UBA3 [cytosol] (Plasmodium falciparum)

UBA3 [cytosol] (Rattus norvegicus)

UBA3 [cytosol] (Saccharomyces cerevisiae)

UBA3 [cytosol] (Schizosaccharomyces pombe)

UBA3 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_003959.3, NP_937838.1

OpenTargets

ENSG00000144744

ENSEMBL

ENST00000361055, ENST00000349511, ENSP00000340041, ENSP00000354340

HPA

ENSG00000144744-UBA3

PRO

Q8TBC4

Pharos - Targets

Q8TBC4

GlyGen

Q8TBC4

PDB

5JJM, 1YOV, 3DBH, 1R4M, 3FN1, 2NVU, 1R4N, 3DBL, 3GZN, 1Y8X, 2LQ7, 1TT5, 3DBR

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61081 UBE2M	5	G76-NEDD8-C111-AcM-UBE2M [cytosol] (R-HSA-4419894) AcM-UBE2M [cytosol] (R-HSA-8951627) UBE2M [cytosol] (R-HSA-947619) G76-NEDD8-C111-AcM-UBE2M [nucleoplasm] (R-HSA-8952508) AcM-UBE2M [nucleoplasm] (R-HSA-8952502)	0.825	5
UniProt:Q96FN4 CPNE2			0.718	6
UniProt:O14732 IMPA2	1	IMPA2 [cytosol] (R-HSA-1604572)	0.718	6
UniProt:Q8TBC4 UBA3	2	UBA3 [cytosol] (R-HSA-947632) G76-NEDD8-C237-UBA3 [cytosol] (R-HSA-8951640)	0.666	4
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.564	6
UniProt:P02649 APOE	10	APOE [endoplasmic reticulum lumen] (R-HSA-6784908) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [extracellular region] (R-HSA-174646) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE-4 [extracellular region] (R-HSA-9711070) APOE [plasma membrane] (R-HSA-174615) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [endosome membrane] (R-HSA-174766) APOE [endosome lumen] (R-HSA-174804) APOE [early endosome] (R-HSA-2429687)	0.556	3
UniProt:Q9BVJ7 DUS23			0.556	3
UniProt:Q13564 NAE1	1	NAE1 [cytosol] (R-HSA-8951449)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3

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