Melanin-concentrating hormone receptors bind MCH

Stable Identifier
R-HSA-947673
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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Melanin-concentrating hormone receptors bind MCH
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Two Melanin-concentrating hormone receptors have been characterized in humans. Many non-human species (rat, mouse, hamster, guinea pig and rabbit) do not have a functional MCHR2 receptor, or encode a nonfunctional MCHR2 pseudogene (Tan et al. 2002). The receptors bind melanin concentrating hormone, a cyclic peptide predominantly expressed in the hypothalamus that functions as a neurotransmitter controlling a range of functions. A major role of MCH is thought to be in the regulation of feeding: injection of MCH into rat brains stimulates feeding; expression of MCH is upregulated in the hypothalamus of obese and fasting mice; and mice lacking MCH are lean and eat less. MCH and alpha melanocyte-stimulating hormone (alpha-MSH) have antagonistic effects on a number of physiological functions. Alpha-MSH darkens pigmentation in fish and reduces feeding in mammals, whereas MCH increases feeding.
Literature References
PubMed ID Title Journal Year
10421367 Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1

Cluderay, J, Martin, J, Leslie, R, Chambers, J, Sarau, HM, Ganguly, S, Liu, WS, Bergsma, D, Konchar, S, Dytko, GM, Hervieu, G, Fitzgerald, LR, Wilson, S, Park, J, Ames, RS, Foley, JJ, Ellis, C, Muir, A

Nature 1999
10421368 Molecular characterization of the melanin-concentrating-hormone receptor

Saito, Y, Leslie, F, Lin, SH, Wang, Z, Nothacker, HP, Civelli, O

Nature 1999
11562423 Cloning and molecular characterization of the novel human melanin-concentrating hormone receptor MCH2

Boutin, JA, Audinot, V, Naime, I, Dromaint, S, Ouvry, C, Rique, H, Rodriguez, M, Beauverger, P, Suply, T, Nagel, N, Souchaud, S, Galizzi, JP

Mol Pharmacol 2001
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Orthologous Events
Melanin-concentrating hormone receptors bind MCH (Bos taurus)
Melanin-concentrating hormone receptors bind MCH (Canis familiaris)
Melanin-concentrating hormone receptors bind MCH (Gallus gallus)
Melanin-concentrating hormone receptors bind MCH (Mus musculus)
Melanin-concentrating hormone receptors bind MCH (Rattus norvegicus)
Melanin-concentrating hormone receptors bind MCH (Sus scrofa)
Melanin-concentrating hormone receptors bind MCH (Xenopus tropicalis)
Authored
Jupe, S  (2010-09-10)
Reviewed
Jassal, B  (2010-06-09)
Created
Jupe, S  (2010-09-10)
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