Reactome | MCHR1 [plasma membrane]

MCHR1 [plasma membrane]

Stable Identifier

R-HSA-947682

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Melanin-concentrating hormone receptor 1, MCHR1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
        
        MCHR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
        
        MCHR1 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
        
        MCHR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
        
        MCHR1 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
        
        MCHR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
        
        MCHR1 [plasma membrane] (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
        
        MCHR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
        
        MCHR1 [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
        
        MCHR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
        
        MCHR1 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
        
        MCHR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
        
        MCHR1 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Melanin-concentrating hormone receptors bind MCH (Homo sapiens)
        
        MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
        
        MCHR1 [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
        
        MCHR1,MCHR2 [plasma membrane] (Homo sapiens)
        
        MCHR1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99705 MCHR1

Gene Names

MCHR1, GPR24, SLC1

Chain

chain:1-353

Reference Genes

BioGPS Gene:2847 MCHR1

COSMIC (genes):MCHR1 MCHR1

CTD Gene:2847 MCHR1

dbSNP Gene:2847 MCHR1

ENSEMBL:ENSG00000128285 MCHR1

ENSEMBL_homo_sapiens_GENE:ENSG00000128285.5 MCHR1

HGNC:4479 MCHR1

KEGG Gene (Homo sapiens):2847 MCHR1

Monarch:2847 MCHR1

NCBI Gene:2847 MCHR1

OMIM:601751 MCHR1

UCSC:Q99705 MCHR1

Reference Transcript

RefSeq:NM_005297.3 MCHR1

Other Identifiers

11725147_at

11756848_a_at

16930486

221354_PM_s_at

221354_s_at

223855_PM_s_at

223855_s_at

230498_PM_at

230498_at

2847

3946496

3946497

3946498

3946499

3946500

54517_at

8073296

A_14_P117741

A_23_P211543

A_33_P3393311

GE59374

GO:0004930

GO:0005102

GO:0005886

GO:0005929

GO:0006091

GO:0007165

GO:0007166

GO:0007186

GO:0007193

GO:0007204

GO:0007218

GO:0007631

GO:0008188

GO:0016020

GO:0023052

GO:0030273

GO:0042562

GO:0042923

GO:0043005

GO:0043226

GO:0051928

GO:0060089

GO:0060170

GO:0097730

HMNXSV003026301

Hs.248122.1.S1_3p_at

ILMN_1685096

PH_hs_0013152

TC22000326.hg

U71092_at

g12804624_3p_a_at

g4885312_3p_a_at

Participates

as a candidate of

BBSome ciliary cargo [plasma membrane] (Homo sapiens)

as a member of

MCHR1,MCHR2 [plasma membrane] (Homo sapiens)

Other forms of this molecule

MCHR1 [ciliary membrane]

Inferred To

npr-16 [plasma membrane] (Caenorhabditis elegans)

npr-26 [plasma membrane] (Caenorhabditis elegans)

AstC-R1 [plasma membrane] (Drosophila melanogaster)

MCHR1 [plasma membrane] (Bos taurus)

MCHR1 [plasma membrane] (Caenorhabditis elegans)

MCHR1 [plasma membrane] (Canis familiaris)

MCHR1 [plasma membrane] (Sus scrofa)

AstC-R2 [plasma membrane] (Drosophila melanogaster)

mchr1.2 [plasma membrane] (Xenopus tropicalis)

npr-23 [plasma membrane] (Caenorhabditis elegans)

Rh7 [plasma membrane] (Drosophila melanogaster)

npr-24 [plasma membrane] (Caenorhabditis elegans)

npr-28 [plasma membrane] (Caenorhabditis elegans)

npr-18 [plasma membrane] (Caenorhabditis elegans)

Mchr1 [plasma membrane] (Mus musculus)

Mchr1 [plasma membrane] (Rattus norvegicus)

Homologues of MCHR1 [plasma membrane] (Caenorhabditis elegans)

Homologues of MCHR1 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_005288.3

Guide to Pharmacology - Targets

280

OpenTargets

ENSG00000128285

ZINC - Substances

MCHR1_HUMAN

ZINC target

Q99705

PRO

Q99705

ZINC - Investigational

MCHR1_HUMAN

HPA

ENSG00000128285-MCHR1

GeneCards

Q99705

Ensembl

ENST00000249016, ENSP00000249016, ENSG00000128285

Pharos - Targets

Q99705

ZINC - Predictions - Purchasable

MCHR1_HUMAN

HMDB Protein

HMDBP13925

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