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PMCH(147-165) [extracellular region]
Stable Identifier
R-HSA-947685
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
MCH, Melanin-concentrating hormone, MCH_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
PMCH(147-165) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
PMCH(147-165) [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
PMCH(147-165) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
PMCH(147-165) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
PMCH(147-165) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
PMCH(147-165) [extracellular region] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
PMCH(147-165) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
PMCH(147-165) [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
PMCH(147-165) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
PMCH(147-165) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
PMCH(147-165) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
PMCH(147-165) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Melanin-concentrating hormone receptors bind MCH (Homo sapiens)
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
PMCH(147-165) [extracellular region] (Homo sapiens)
PMCH(147-165) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20382 PMCH
Gene Names
PMCH, MCH
Chain
signal peptide:1-21, chain:22-165, peptide:110-128, peptide:131-143, peptide:147-165
Reference Genes
BioGPS Gene:5367 PMCH
COSMIC (genes):PMCH PMCH
CTD Gene:5367 PMCH
dbSNP Gene:5367 PMCH
ENSEMBL:ENSG00000183395 PMCH
ENSEMBL_homo_sapiens_GENE:ENSG00000183395.5 PMCH
HGNC:9109 PMCH
KEGG Gene (Homo sapiens):5367 PMCH
Monarch:5367 PMCH
NCBI Gene:5367 PMCH
OMIM:176795 PMCH
UCSC:P20382 PMCH
Reference Transcript
RefSeq:NM_002674.3 PMCH
Other Identifiers
11733425_at
16769244
206942_PM_s_at
206942_s_at
32005_at
3468304
3468305
3468306
3468308
3468309
3468310
3468311
3468312
5367
7965867
A_23_P321223
GO:0005179
GO:0005576
GO:0005634
GO:0007218
GO:0007268
GO:0007283
GO:0007631
GO:0022414
GO:0023052
GO:0030154
GO:0030354
GO:0031777
GO:0043226
GO:0045202
GO:0048018
GO:0098772
HMNXSV003033358
ILMN_1654429
ILMN_2170095
M57703_s_at
PH_hs_0000290
TC12001888.hg
g4505898_3p_at
Participates
as a member of
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
as an input of
Melanin-concentrating hormone receptors bind MCH (Homo sapiens)
as a component of
MCHR1,MCHR2:PMCH(147-165) [plasma membrane] (Homo sapiens)
Inferred To
pmch [extracellular region]
(Xenopus tropicalis)
Pmch [extracellular region]
(Mus musculus)
Pmch [extracellular region]
(Rattus norvegicus)
PMCH [extracellular region]
(Bos taurus)
PMCH [extracellular region]
(Canis familiaris)
PMCH [extracellular region]
(Gallus gallus)
PMCH [extracellular region]
(Sus scrofa)
pmchl [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_002665.2
OpenTargets
ENSG00000183395
GeneCards
P20382
HPA
ENSG00000183395-PMCH
Ensembl
ENSG00000183395
,
ENST00000329406
,
ENSP00000332225
PRO
P20382
Pharos - Targets
P20382
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