Reactome | UBA2 [nucleoplasm]

UBA2 [nucleoplasm]

Stable Identifier

R-HSA-947696

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SUMO-activating enzyme subunit 2, SAE2_HUMAN

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Literature References

PubMed ID	Title	Journal	Year
11481243	Expression and regulation of the mammalian SUMO-1 E1 enzyme Cavenagh, MM, Azuma, Y, Tan, SH, Saitoh, H, Ainsztein, AM, Dasso, M	FASEB J.	2001

External Reference Information

External Reference

UniProt:Q9UBT2 UBA2

Gene Names

UBA2, SAE2, UBLE1B, HRIHFB2115

Chain

chain:1-640

Reference Genes

BioGPS Gene:10054 UBA2

COSMIC (genes):UBA2 UBA2

CTD Gene:10054 UBA2

dbSNP Gene:10054 UBA2

ENSEMBL:ENSG00000126261 UBA2

HGNC:30661 UBA2

KEGG:hsa:10054 UBA2

Monarch:10054 UBA2

NCBI Gene:10054 UBA2

OMIM:613295 UBA2

UCSC:Q9UBT2 UBA2

Reference Transcript

RefSeq:NM_005499.2 UBA2

Other Identifiers

10054

11717530_a_at

11717531_x_at

11749584_a_at

11758626_s_at

16860746

201177_PM_s_at

201177_s_at

229587_PM_at

229587_at

2345219

2928376

2928377

2928378

2928380

34814_at

3829769

3829770

3829771

3829772

3829773

3829774

3829775

3829776

3829777

3829778

3829780

3829781

3829782

3829787

3829788

3829790

3829791

3829792

3829793

3829795

3829798

3829800

3829801

3829803

3829804

3829805

3829808

3829809

3829810

3829811

3829812

3829813

3829814

74323_at

8027650

A_14_P117512

A_24_P376229

A_24_P926935

GE717975

GE79556

GO:0000287

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0008641

GO:0016740

GO:0016874

GO:0016925

GO:0019948

GO:0031510

GO:0032183

GO:0033235

GO:0043226

GO:0044388

GO:0044390

GO:0046872

GO:0046982

GO:0140096

GO:0140657

HMNXSV003054824

Hs.4311.1.A1_3p_at

ILMN_1742872

PH_hs_0028596

PH_hs_0040878

TC19000444.hg

g4885648_3p_a_at

g4885648_3p_x_at

Participates

as a component of

UBA2:SAE1 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

SUMO1-C173-UBA2 [nucleoplasm]

SUMO2-C173-UBA2 [nucleoplasm]

SUMO3-C173-UBA2 [nucleoplasm]

Inferred To

UBA2 [nucleoplasm] (Bos taurus)

UBA2 [nucleoplasm] (Caenorhabditis elegans)

UBA2 [nucleoplasm] (Canis familiaris)

UBA2 [nucleoplasm] (Danio rerio)

UBA2 [nucleoplasm] (Dictyostelium discoideum)

UBA2 [nucleoplasm] (Drosophila melanogaster)

UBA2 [nucleoplasm] (Gallus gallus)

UBA2 [nucleoplasm] (Mus musculus)

UBA2 [nucleoplasm] (Rattus norvegicus)

UBA2 [nucleoplasm] (Saccharomyces cerevisiae)

UBA2 [nucleoplasm] (Schizosaccharomyces pombe)

UBA2 [nucleoplasm] (Sus scrofa)

UBA2 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_005490.1

ENSEMBL

ENSP00000437484, ENST00000439527, ENSP00000246548, ENST00000246548

OpenTargets

ENSG00000126261

HPA

ENSG00000126261-UBA2

PRO

Q9UBT2

Pharos - Targets

Q9UBT2

GlyGen

Q9UBT2

HMDB Protein

HMDBP09256

PDB

4W5V, 6XOI, 1Y8R, 2PX9, 1Y8Q, 6CWY, 3KYC, 6CWZ, 3KYD, 6XOG, 6XOH, 5FQ2

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [cytosol] (R-HSA-4655342)	0.85	9
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.85	9
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	6

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