Reactome | UBA1 [cytosol]

UBA1 [cytosol]

Stable Identifier

R-HSA-947698

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin-like modifier-activating enzyme 1, UBA1_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q76353 Q76353

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Literature References

PubMed ID	Title	Journal	Year
21816346	Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins Lee, PC, Sowa, ME, Gygi, SP, Harper, JW	Mol. Cell	2011
8010951	Nuclear localization of the ubiquitin-activating enzyme, E1, is cell-cycle-dependent Grenfell, SJ, Trausch-Azar, JS, Handley-Gearhart, PM, Ciechanover, A, Schwartz, AL	Biochem. J.	1994

External Reference Information

External Reference

UniProt:P22314 UBA1

Gene Names

UBA1, A1S9T, UBE1

Chain

initiator methionine:1, chain:2-1058, initiator methionine:1

Reference Genes

BioGPS Gene:7317 UBA1

COSMIC (genes):UBA1 UBA1

CTD Gene:7317 UBA1

dbSNP Gene:7317 UBA1

ENSEMBL:ENSG00000130985 UBA1

HGNC:12469 UBA1

KEGG:hsa:7317 UBA1

Monarch:7317 UBA1

NCBI Gene:7317 UBA1

OMIM:314370 UBA1

UCSC:P22314 UBA1

Reference Transcript

Other Identifiers

11715371_a_at

1268_at

17103024

200964_PM_at

200964_at

3976063

3976064

3976065

3976066

3976067

3976068

3976069

3976070

3976071

3976072

3976073

3976074

3976075

3976076

3976077

3976078

3976079

3976080

3976081

3976082

3976083

3976084

3976085

3976086

3976087

3976088

3976089

3976090

3976091

3976092

3976093

3976094

3976095

3976097

3976098

3976099

3976100

3976101

3976103

3976104

3976106

3976108

3976109

3976110

3976114

3976116

3976117

3976118

3976119

60652_at

7317

74862_at

8167069

A_23_P137209

A_24_P237374

GE57988

GO:0000166

GO:0000792

GO:0003723

GO:0003824

GO:0004839

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005765

GO:0005829

GO:0006511

GO:0006974

GO:0008641

GO:0010008

GO:0016567

GO:0016874

GO:0030057

GO:0030867

GO:0032446

GO:0036211

GO:0070062

GO:0140096

GO:0140657

HMNXSV003003863

ILMN_1683609

ILMN_1720764

M58028_at

PH_hs_0024681

TC0X000228.hg

g4507762_3p_at

Participates

as a component of

as an input of

UBA1 adenylates ubiquitin in the cytosol (Homo sapiens)

as a candidate of

Ubiquitin activating E1 enzymes [cytosol] (Homo sapiens)

Other forms of this molecule

UBA1 [nucleoplasm]

Inferred To

ptr3 [cytosol] (Schizosaccharomyces pombe)

uba-1 [cytosol] (Caenorhabditis elegans)

uba1 [cytosol] (Danio rerio)

uba1 [cytosol] (Dictyostelium discoideum)

uba1 [cytosol] (Xenopus tropicalis)

Homologues of UBA1 [cytosol] (Danio rerio)

Homologues of UBA1 [cytosol] (Plasmodium falciparum)

Uba1 [cytosol] (Drosophila melanogaster)

Uba1 [cytosol] (Mus musculus)

Uba1 [cytosol] (Rattus norvegicus)

UBA7 [cytosol] (Gallus gallus)

UBA1 [cytosol] (Bos taurus)

UBA1 [cytosol] (Canis familiaris)

UBA1 [cytosol] (Plasmodium falciparum)

UBA1 [cytosol] (Saccharomyces cerevisiae)

UBA1 [cytosol] (Sus scrofa)

uba7 [cytosol] (Danio rerio)

Cross References

RefSeq

XP_054183670.1, XP_054183671.1, XP_016885270.1, NP_003325.2, XP_016885269.1, NP_695012.1, XP_047298380.1, XP_047298381.1

OpenTargets

ENSG00000130985

ENSEMBL

ENSP00000338413, ENSG00000130985, ENST00000335972, ENST00000377351, ENSP00000366568

ZINC - Substances

UBA1_HUMAN

ZINC target

P22314

PRO

P22314

GlyGen

P22314

PDB

4P22, 6DC6, 7PYV

HPA

ENSG00000130985-UBA1

GeneCards

UBA1

Pharos - Targets

P22314

Orphanet

UBA1

HMDB Protein

HMDBP00618

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.73	4
IntAct:EBI-4399559 UBIQ			0.667	4
UniProt:Q96FW1 OTUB1	2	OTUB1 [cytosol] (R-HSA-933411) OTUB1 [nucleoplasm] (R-HSA-6783242)	0.666	4
UniProt:P61088 UBE2N	5	UBE2N [cytosol] (R-HSA-206072) Ub-C87-UBE2N [cytosol] (R-HSA-8864210) UBE2N [nucleoplasm] (R-HSA-5682541) K63polyUb-C87-UBE2N [nucleoplasm] (R-HSA-6790511) Ub-C87-UBE2N [nucleoplasm] (R-HSA-8943013)	0.638	3
UniProt:Q13489 BIRC3	3	BIRC3 [cytosol] (R-HSA-50845) K48pUb-BIRC3 [cytosol] (R-HSA-5675478) K63polyUb-BIRC3 [cytosol] (R-HSA-5668478)	0.59	2
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.556	3
UniProt:Q9BUZ4 TRAF4			0.556	3
UniProt:P57078 RIPK4			0.527	2
UniProt:Q13618 CUL3	3	CUL3 [cytosol] (R-HSA-975979) CUL3 [nucleoplasm] (R-HSA-5635033) G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516)	0.527	2
UniProt:Q9H2C0 GAN	1	GAN [cytosol] (R-HSA-976014)	0.527	3
UniProt:Q9UBF1 MAGC2			0.525	2
UniProt:Q76353 Q76353			0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	8

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