Unknown caspase cleaves NTRK3

Stable Identifier
R-HSA-9603534
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Unknown caspase cleaves NTRK3
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In the absence of ligand, NTRK3 (TRKC) is cleaved by an unknown caspase. CASP3 (caspase-3) cleaves NTRK3 in vitro, but CASP3 inhibitors do not prevent NTRK3 cleavage in live cells. CASP8 (caspase-8) is unable to cleave NTRK3 in vitro. A general caspase inhibitor prevents NTRK3 cleavage in live cells (Tauszig-Delamasure et al. 2007).
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Output
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Catalyst Activity

cysteine-type endopeptidase activity of unidentified caspase [cytosol]

Physical Entity
unidentified caspase [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Inferred From
Unknown caspase cleaves Ntrk3 (Mus musculus)
Authored
Orlic-Milacic, M  (2018-01-02)
Reviewed
Tsoulfas, P  (2018-05-09)
Created
Orlic-Milacic, M  (2018-03-22)
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