NICD4 traffics to the nucleus

Stable Identifier
R-HSA-9604308
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nuclear envelope
ReviewStatus
5/5
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NICD4 traffics to the nucleus
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The cytosolic NICD4 translocates to the nucleus. Trafficking of NICD4 to the nucleus is negatively regulated by binding of NICD4 to 14-3-3-zeta (YWHAZ), which happens upon NICD4 phosphorylation by activated AKT1 (Ramakrishnan et al. 2015).
Literature References
PubMed ID Title Journal Year
25740432 AKT and 14-3-3 regulate Notch4 nuclear localization

Green, AR, Davaakhuu, G, Pannuti, A, Ramakrishnan, G, Zhu, H, Chung, WC, Miele, L, Atfi, A, Tzivion, G, Rana, A, Filipovic, A

Sci Rep 2015
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
positive regulation of Notch signaling pathway (0045747)
This event is regulated
Negatively by
Regulator
p-4S-NICD4:YWHAZ dimer [cytosol] (Homo sapiens)
Active Unit
YWHAZ dimer [cytosol]
Orthologous Events
NICD4 traffics to the nucleus (Bos taurus)
NICD4 traffics to the nucleus (Caenorhabditis elegans)
NICD4 traffics to the nucleus (Drosophila melanogaster)
NICD4 traffics to the nucleus (Gallus gallus)
NICD4 traffics to the nucleus (Mus musculus)
NICD4 traffics to the nucleus (Rattus norvegicus)
NICD4 traffics to the nucleus (Sus scrofa)
Authored
Jassal, B  (2004-12-15)
Orlic-Milacic, M  (2018-04-05)
Reviewed
Joutel, A  (2004-12-15)
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2018-04-02)
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