AKT1 phosphorylates NOTCH4

Stable Identifier
R-HSA-9604328
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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AKT1 phosphorylates NOTCH4
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Recombinant human AKT1 phosphorylates recombinant human NICD4 on four AKT-target sites conserved in primates: S1495, S1847, S1865 and S1917 (Ramakrishnan et al. 2015).

Literature References
PubMed ID Title Journal Year
25740432 AKT and 14-3-3 regulate Notch4 nuclear localization

Green, AR, Davaakhuu, G, Pannuti, A, Ramakrishnan, G, Zhu, H, Chung, WC, Miele, L, Atfi, A, Tzivion, G, Rana, A, Filipovic, A

Sci Rep 2015
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
negative regulation of Notch signaling pathway (0045746)
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-AKT1 [cytosol]

Physical Entity
p-T308,S473-AKT1 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
AKT1 phosphorylates NOTCH4 (Caenorhabditis elegans)
AKT1 phosphorylates NOTCH4 (Canis familiaris)
AKT1 phosphorylates NOTCH4 (Danio rerio)
AKT1 phosphorylates NOTCH4 (Drosophila melanogaster)
AKT1 phosphorylates NOTCH4 (Gallus gallus)
AKT1 phosphorylates NOTCH4 (Mus musculus)
AKT1 phosphorylates NOTCH4 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2018-04-05)
Reviewed
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2018-04-03)
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