Reactome | HEY1 gene expression is stimulated by NOTCH4

HEY1 gene expression is stimulated by NOTCH4

Stable Identifier

R-HSA-9604550

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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HEY1 gene expression is stimulated by NOTCH4

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Increased NOTCH4 levels correlate with increased HEY1 gene expression (Tsunematsu et al. 2004, Simoes et al. 2015, Bonyadi Rad et al. 2016, Fukusumi et al. 2018). NOTCH4-mediated upregulation of HEY1 in head and neck squamous cell carcinoma (HNSCC) is associated with epithelial-to-mesenchymal transition (EMT) phenotype (Fukusumi et al. 2018). In melanoma, however, HEY1 and HEY2 expression downstream of NOTCH4 is associated with mesenchymal-to-epithelial-like transition and reduced invasiveness (Bonyadi Rad et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
14672936	Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development Tsunematsu, R, Oike, Y, Bessho, Y, Hatakeyama, S, Nakayama, KI, Suda, T, Nakayama, K, Kageyama, R, Ishida, N, Nishiyama, M	J. Biol. Chem.	2004
26387946	Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity Sims, AH, Brennan, K, Howell, SJ, Yu, L, Ucar, A, Alférez, DG, Gandhi, A, Farnie, G, Gee, J, Silva, A, Howell, A, Rydén, L, Clarke, RB, Catalano, S, Santiago-Gómez, A, Landberg, G, Marangoni, E, Eyre, R, Simões, BM, Spence, K, Chemi, F, O'Brien, CS, Andó, S, Acar, A, Sarmiento-Castro, A	Cell Rep	2015
26801977	Notch4 Signaling Induces a Mesenchymal-Epithelial-like Transition in Melanoma Cells to Suppress Malignant Behaviors Bonyadi Rad, E, Bergler, H, Hafner, C, Hammerlindl, H, Ravindran Menon, D, Schaider, H, Herlyn, M, Popper, U, Breiteneder, H, Wels, C, Kitzwoegerer, M	Cancer Res.	2016
29146722	The NOTCH4-HEY1 Pathway Induces Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma Gutkind, JS, Sakai, A, Liu, C, Guo, TW, Califano, JA, Fukusumi, T, Haft, S, Ando, M, Ren, S, Amornphimoltham, P	Clin. Cancer Res.	2018