Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2B (GRIN2B)

Stable Identifier
R-HSA-9609744
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2B (GRIN2B)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
GluN2B (GRIN2B) forms a di-heterotetramer with GluN1 (GRIN1). The tetramer includes two molecules of GluN1 and two molecules of GluN2B. GluN2B expression starts during embryonic development and continues in adult brain (Monyer et al. 1992, Sheng et al. 1994). The tetrameric structure is deduced from the crystal structure of the rat GluN1:GluN2B (Grin1:Grin2b) NMDA receptor (Karakas and Furukawa 2014) and the Xenopus GluN1:GluN2B NMDA receptor (Lee et al. 2014).
Participants
Input
Output
Participates
as an event of
Inferred From
Formation of di-heterotetramers of GluN1 and GluN2b (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2019-01-05)
Reviewed
Traynelis, SF  (2019-02-11)
Camp, C  (2019-02-11)
Bhattacharya, S  (2019-02-11)
Created
Orlic-Milacic, M  (2018-06-01)
Cite Us!