Reactome | GRIN1 [endoplasmic reticulum membrane]

GRIN1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9609763

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Glutamate (NMDA) receptor subunit zeta-1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q05586 GRIN1

Gene Names

GRIN1, NMDAR1

Chain

signal peptide:1-18, chain:19-938

Reference Genes

BioGPS Gene:2902 GRIN1

COSMIC (genes):GRIN1 GRIN1

CTD Gene:2902 GRIN1

dbSNP Gene:2902 GRIN1

ENSEMBL:ENSG00000176884 GRIN1

HGNC:4584 GRIN1

KEGG:hsa:2902 GRIN1

Monarch:2902 GRIN1

NCBI Gene:2902 GRIN1

OMIM:138249 GRIN1

UCSC:Q05586 GRIN1

Reference Transcript

Participates

as an input of

as a component of

Other forms of this molecule

GRIN1 [plasma membrane]

GRIN1 [transport vesicle membrane]

Inferred To

grin1b [endoplasmic reticulum membrane] (Danio rerio)

Nmdar1 [endoplasmic reticulum membrane] (Drosophila melanogaster)

nmr-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

grin1 [endoplasmic reticulum membrane] (Xenopus tropicalis)

GRIN1 [endoplasmic reticulum membrane] (Canis familiaris)

GRIN1 [endoplasmic reticulum membrane] (Gallus gallus)

GRIN1 [endoplasmic reticulum membrane] (Sus scrofa)

Grin1 [endoplasmic reticulum membrane] (Mus musculus)

Grin1 [endoplasmic reticulum membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_015566.1, NP_067544.1, NP_000823.4, XP_054218781.1, NP_001172020.1, XP_054218782.1, NP_001172019.1, XP_005266130.1, XP_005266128.1

ZINC - World Drugs

NMDZ1_HUMAN

Guide to Pharmacology - Targets

455

OpenTargets

ENSG00000176884

ENSEMBL

ENST00000371559, ENST00000371553, ENSP00000360608, ENST00000371546, ENSP00000360605, ENSP00000360614, ENSP00000360615, ENST00000371550, ENSP00000360601, ENSP00000360616, ENST00000371561, ENST00000371560, ENSG00000176884

ZINC - FDA approved

NMDZ1_HUMAN

ZINC - Substances

NMDZ1_HUMAN

ZINC target

Q05586

PRO

Q05586

GlyGen

Q05586

PDB

7YFM, 7YFO, 9GIC, 9GIE, 3BYA, 9D39, 9D37, 9D3B, 8VUV, 2NR1, 2HQW, 5KDT, 7EOU, 8UUE, 5H8Q, 7EU8, 9GIG, 5H8N, 8JIZ, 8E97, 9GJ1, 6IRA, 9D3A, 5H8H, 8E98, 6IRH, 8VUT, 8E92, 7EOQ, 8VUL, 5TP9, 5TPA, 8VUQ, 8JJ0, 7EU7, 7YFF, 9GIF, 9GID, 7YFL, 9D38, 7YFR, 8VUU, 8VUS, 8Y1V, 8E96, 6IRF, 5I2K, 8E99, 5KCJ, 8E93, 8VUR, 5I2N, 8JJ1, 6IRG, 9GIB, 9D3C, 7EOR, 7EOT, 7EOS, 8VUN, 8E94, 8JJ2, 5H8F

HPA

ENSG00000176884-GRIN1

GeneCards

GRIN1

Pharos - Targets

Q05586

Orphanet

GRIN1

ZINC - Predictions - Purchasable

NMDZ1_HUMAN

HMDB Protein

HMDBP01635

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.556	3

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