Activated MAP2K1 and MAP2K2 dimers phosphorylate MAPK1 and MAPK3 downstream of NGF stimulation and RAP1 activation at the endosome (Kao et al, 2001; Wu et al, 2001; reviewed in Huang and Reichardt, 2003; Reichardt, 2006).
Kao, S, Kolch, W, Landreth, GE, Jaiswal, RK
Reichardt, LF
Reichardt, LF, Huang, EJ
Mobley, WC, Lai, CF
protein serine/threonine kinase activity of RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane]
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