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GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane]
Stable Identifier
R-HSA-9611031
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Assembly and cell surface presentation of NMDA receptors (Homo sapiens)
CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GluN1 (GRIN1) binds to ACTN2 at postsynaptic density (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
Negative regulation of NMDA receptor-mediated neuronal transmission (Homo sapiens)
CALM1:4xCa2+ binds GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors and displaces ACTN2 (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
Long-term potentiation (Homo sapiens)
SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
Unblocking of NMDA receptors, glutamate binding and activation (Homo sapiens)
Ca2+ influx into the post-synaptic cell (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
Mg2+ binds GRIN1:GRIN2 NMDA receptors (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
Unblocking of GRIN1:GRIN2 NMDA receptors (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
Participants
components
ACTN2 homodimer [cytosol]
(Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane]
(Homo sapiens)
Participates
as an input of
CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density (Homo sapiens)
as an output of
GluN1 (GRIN1) binds to ACTN2 at postsynaptic density (Homo sapiens)
as a component of
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
Inferred To
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane]
(Bos taurus)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane]
(Caenorhabditis elegans)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane]
(Canis familiaris)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane]
(Danio rerio)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane]
(Drosophila melanogaster)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane]
(Gallus gallus)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane]
(Mus musculus)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane]
(Rattus norvegicus)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane]
(Sus scrofa)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane]
(Xenopus tropicalis)
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