Reactome | LRRC7 [cytosol]

LRRC7 [cytosol]

Stable Identifier

R-HSA-9611351

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Leucine-rich repeat-containing protein 7, LRRC7_HUMAN, Densin-180

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Assembly and cell surface presentation of NMDA receptors (Homo sapiens)
        
        CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        LRRC7 [cytosol] (Homo sapiens)
        
        LRRC7 [cytosol] (Homo sapiens)
      - Negative regulation of NMDA receptor-mediated neuronal transmission (Homo sapiens)
        
        CALM1:4xCa2+ binds GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors and displaces ACTN2 (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        LRRC7 [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:LRRC7:CaMKII dodecamer [plasma membrane] (Homo sapiens)
        
        LRRC7 [cytosol] (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
        
        Ras activation upon Ca2+ influx through NMDA receptor (Homo sapiens)
        
        Activation of RasGRF (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        LRRC7 [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        LRRC7 [cytosol] (Homo sapiens)
        
        NMDA-activated RASGRF1 activates RAS (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        LRRC7 [cytosol] (Homo sapiens)
        
        Long-term potentiation (Homo sapiens)
        
        CaMKII binds activated NMDA receptor (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        LRRC7 [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        LRRC7 [cytosol] (Homo sapiens)
        
        CaMKII phosphorylates AMPA receptor (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        LRRC7 [cytosol] (Homo sapiens)
        
        SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        LRRC7 [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:p-Y-GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:p-Y-GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        LRRC7 [cytosol] (Homo sapiens)
      - Unblocking of NMDA receptors, glutamate binding and activation (Homo sapiens)
        
        Ca2+ influx into the post-synaptic cell (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        LRRC7 [cytosol] (Homo sapiens)
        
        Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        LRRC7 [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        LRRC7 [cytosol] (Homo sapiens)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        LRRC7 [cytosol] (Homo sapiens)
        
        Mg2+ binds GRIN1:GRIN2 NMDA receptors (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        LRRC7 [cytosol] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        LRRC7 [cytosol] (Homo sapiens)
        
        Unblocking of GRIN1:GRIN2 NMDA receptors (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        LRRC7 [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        LRRC7 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
        
        RAS GEFs [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        LRRC7 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96NW7 LRRC7

Gene Names

LRRC7, KIAA1365, LAP1

Chain

chain:1-1537

Reference Genes

COSMIC (genes):LRRC7 LRRC7

ENSEMBL:ENSG00000033122 LRRC7

HGNC:18531 LRRC7

OMIM:614453 LRRC7

UCSC:Q96NW7 LRRC7

Reference Transcript

RefSeq:NM_020794.2 LRRC7

Participates

as a component of

as an input of

CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density (Homo sapiens)

Other forms of this molecule

LRRC7 [extracellular region]

LRRC7 [specific granule lumen]

Inferred To

scrib [cytosol] (Drosophila melanogaster)

let-413 [cytosol] (Caenorhabditis elegans)

Lrrc7 [cytosol] (Mus musculus)

Lrrc7 [cytosol] (Rattus norvegicus)

LRRC7 [cytosol] (Bos taurus)

LRRC7 [cytosol] (Canis familiaris)

LRRC7 [cytosol] (Gallus gallus)

LRRC7 [cytosol] (Sus scrofa)

Ghost homologue of LRRC7 [cytosol] (Danio rerio)

Ghost homologue of LRRC7 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_065845.1

OpenTargets

ENSG00000033122

GeneCards

Q96NW7

PRO

Q96NW7

Pharos - Targets

Q96NW7

PDB

6X5G, 7QQM

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Z1T4	1	Cnksr2 [cytosol] (R-RNO-5672632)	0.508	2
UniProt:O14656 TOR1A	1	TOR1A [cytosol] (R-HSA-8862858)	0.488	2
UniProt:Q9Y566 SHANK1	1	SHANK1 [cytosol] (R-HSA-6794274)	0.488	2

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