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CaMKII dodecamer [cytosol]
Stable Identifier
R-HSA-9611355
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
CAMK2 dodecamer
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Assembly and cell surface presentation of NMDA receptors (Homo sapiens)
CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
Negative regulation of NMDA receptor-mediated neuronal transmission (Homo sapiens)
CALM1:4xCa2+ binds GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors and displaces ACTN2 (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:LRRC7:CaMKII dodecamer [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
PPM1F dephosphorylates p-T286-CaMKII (Homo sapiens)
CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
Ras activation upon Ca2+ influx through NMDA receptor (Homo sapiens)
Activation of RasGRF (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
NMDA-activated RASGRF1 activates RAS (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
Long-term potentiation (Homo sapiens)
CaMKII autophosphorylates (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CaMKII binds activated NMDA receptor (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CaMKII binds activated calmodulin (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CaMKII phosphorylates AMPA receptor (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:p-Y-GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:p-Y-GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
Unblocking of NMDA receptors, glutamate binding and activation (Homo sapiens)
Ca2+ influx into the post-synaptic cell (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
Membrane depolarization upon activation of Ca impermeable AMPA receptors (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
Mg2+ binds GRIN1:GRIN2 NMDA receptors (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
Unblocking of GRIN1:GRIN2 NMDA receptors (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
CaMKII autophosphorylates (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CaMKII binds activated calmodulin (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
Ca-dependent events (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
CaMKII autophosphorylates (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CaMKII binds activated calmodulin (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
CaMKII dodecamer [cytosol] (Homo sapiens)
General
CaMKII is composed of a homo or hetero dodecamer of four subunits apha, beta, delta and gamma. In a heteromultimer the ratio of alpha to beta may vary from 6;1, 3:1 or 1:1.
Participants
components
x 12
CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol]
(Homo sapiens)
Participates
as a component of
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:LRRC7:CaMKII dodecamer [plasma membrane] (Homo sapiens)
GRIN1:p-Y-GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
as an input of
CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density (Homo sapiens)
CaMKII binds activated calmodulin (Homo sapiens)
Inferred To
CaMKII dodecamer [cytosol]
(Bos taurus)
CaMKII dodecamer [cytosol]
(Caenorhabditis elegans)
CaMKII dodecamer [cytosol]
(Canis familiaris)
CaMKII dodecamer [cytosol]
(Danio rerio)
CaMKII dodecamer [cytosol]
(Drosophila melanogaster)
CaMKII dodecamer [cytosol]
(Gallus gallus)
CaMKII dodecamer [cytosol]
(Mus musculus)
CaMKII dodecamer [cytosol]
(Rattus norvegicus)
CaMKII dodecamer [cytosol]
(Sus scrofa)
CaMKII dodecamer [cytosol]
(Xenopus tropicalis)
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