SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs

Stable Identifier
R-HSA-9612085
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs
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Non-receptor tyrosine kinase SRC phosphorylates GluN2 (GRIN2, NR2) subunits of the GluN2-containing NMDA receptors. This increases NMDA receptor open time and activity (Yu et al. 1997) and plays a role in long-term potentiation. SRC-mediated phosphorylation of NMDA receptors (NMDARs) is reduced in schizophrenia. Activation of ERBB4 signaling negatively regulates phosphorylation of NMDARs by SRC. ERBB4 signaling is hyperactivated in schizophrenia (Pitcher et al. 2011, Banerjee et al. 2015).
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of MyrG-p-Y419-SRC [plasma membrane]

Physical Entity
MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
This event is regulated
Negatively by
Regulator
NRG1:p-ERBB4 homodimers [plasma membrane] (Homo sapiens)
Inferred From
Src phosphorylates GluN2 (Grin2) subunits of NMDARs (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Created
Orlic-Milacic, M  (2018-06-26)
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