Reactome | p-Y-GRIN2B [plasma membrane]

p-Y-GRIN2B [plasma membrane]

Stable Identifier

R-HSA-9612185

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p-Y-GluN2B, p-Y-NR2B

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        Long-term potentiation (Homo sapiens)
        
        SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:p-Y-GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:p-Y-GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        GRIN1:p-Y-GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
        
        GRIN1:p-Y-GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        GRIN1:p-Y-GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:p-Y-GRIN2A,C,D di-heteromers,GRIN1:p-Y-GRIN2 tri-heteromers [plasma membrane] (Homo sapiens)
        
        GRIN1:p-Y-GRIN2B:p-Y-GRIN2D tri-heterotetramer [plasma membrane] (Homo sapiens)
        
        p-Y-GRIN2B [plasma membrane] (Homo sapiens)
        
        GRIN1:p-Y-GRIN2B di-heterotetramer [plasma membrane] (Homo sapiens)
        
        p-Y-GRIN2B [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13224 GRIN2B

Gene Names

GRIN2B, NMDAR2B

Chain

signal peptide:1-26, chain:27-1484

Reference Genes

BioGPS Gene:2904 GRIN2B

COSMIC (genes):GRIN2B GRIN2B

CTD Gene:2904 GRIN2B

dbSNP Gene:2904 GRIN2B

ENSEMBL:ENSG00000273079 GRIN2B

HGNC:4586 GRIN2B

KEGG:hsa:2904 GRIN2B

Monarch:2904 GRIN2B

NCBI Gene:2904 GRIN2B

OMIM:138252 GRIN2B

UCSC:Q13224 GRIN2B

Reference Transcript

Other Identifiers

11737021_at

11737022_at

16761707

210411_PM_s_at

210411_s_at

210412_PM_at

210412_at

239095_PM_at

239095_at

2904

32489_at

3445310

3445312

3445314

3445316

3445318

3445319

3445321

3445323

3445325

3445327

3445328

3445329

3445330

3445335

3445336

3445349

3445350

3445351

3445352

3445354

3445359

3445363

3445390

3445432

3445433

3445458

3445459

3445460

3445464

3445465

3445466

51319_at

7961422

A_19_P00809362

A_23_P151264

A_32_P144072

GE58237

GE756458

GO:0001540

GO:0004970

GO:0004972

GO:0005215

GO:0005216

GO:0005515

GO:0005737

GO:0005764

GO:0005768

GO:0005770

GO:0005773

GO:0005789

GO:0005856

GO:0005886

GO:0006811

GO:0007215

GO:0007268

GO:0007420

GO:0007611

GO:0008270

GO:0009986

GO:0014069

GO:0015276

GO:0016020

GO:0016594

GO:0016595

GO:0017146

GO:0019722

GO:0022849

GO:0022890

GO:0023052

GO:0031090

GO:0031410

GO:0034220

GO:0035235

GO:0035249

GO:0038023

GO:0043005

GO:0043226

GO:0045202

GO:0045211

GO:0045471

GO:0046872

GO:0048167

GO:0048168

GO:0048856

GO:0050877

GO:0051290

GO:0051968

GO:0055085

GO:0060079

GO:0060089

GO:0060291

GO:0065003

GO:0097060

GO:0097553

GO:0098655

GO:0098839

GO:0098976

GO:0099505

GO:0099507

GO:1902951

GO:1904062

GO:1904315

GO:2000463

GO:2001056

HMNXSV003034735

HMNXSV003043145

Hs.292597.0.A1_3p_at

ILMN_1884244

ILMN_1908923

PH_hs_0000159

TC12001265.hg

U11287_at

U28758_s_at

g1899201_3p_a_at

g560546_3p_at

Participates

as a component of

Other forms of this molecule

GRIN2B [plasma membrane]

GRIN2B [endoplasmic reticulum membrane]

GRIN2B [transport vesicle membrane]

p-Y1474-GRIN2B [plasma membrane]

p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane]

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_011518930.1, XP_011518931.1, XP_016874708.1, NP_000825.2

ZINC - World Drugs

NMDE2_HUMAN

Guide to Pharmacology - Targets

457

OpenTargets

ENSG00000273079

ENSEMBL

ENST00000609686, ENSP00000477455

ZINC - Substances

NMDE2_HUMAN

ZINC - Biogenic

NMDE2_HUMAN

ZINC target

Q13224

PRO

Q13224

GlyGen

Q13224

PDB

5EWJ, 7KL1, 7EU8, 7KL0, 7KL2, 7UJP, 7UJR, 7UJT, 7UIS, 5EWL, 5EWM, 7UJQ, 7UJS

ZINC - Investigational

NMDE2_HUMAN

ZINC - Metabolites

NMDE2_HUMAN

HPA

ENSG00000273079-GRIN2B

Pharos - Targets

Q13224

Orphanet

GRIN2B

ZINC - Predictions - Purchasable

NMDE2_HUMAN

HMDB Protein

HMDBP01644

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78352 DLG4	3	DLG4 [plasma membrane] (R-HSA-202135) DLG4 [endocytic vesicle membrane] (R-HSA-416847) DLG4 [cytosol] (R-HSA-6794267)	0.755	4
UniProt:Q12959 DLG1	4	DLG1 [endoplasmic reticulum membrane] (R-HSA-9610593) DLG1 [transport vesicle membrane] (R-HSA-9610631) DLG1 [cytosol] (R-HSA-416332) DLG1 [plasma membrane] (R-HSA-375977)	0.704	4
UniProt:Q9UQM7 CAMK2A	6	p-T286-CAMK2A [cytosol] (R-HSA-445368) CAMK2A [cytosol] (R-HSA-4332329) p-T286-CAMK2A [endocytic vesicle membrane] (R-HSA-416999) p-T286,T305,T306-CAMK2A [cytosol] (R-HSA-4332334) p-T286-CAMK2A [nucleoplasm] (R-HSA-444797) p-T286-CAMK2A [plasma membrane] (R-HSA-432796)	0.602	3
UniProt:P31016 Dlg4	3	Dlg4 [plasma membrane] (R-RNO-9612601) Dlg4 [endocytic vesicle membrane] (R-RNO-416847) Dlg4 [cytosol] (R-RNO-6794248)	0.558	2
UniProt:Q62936	2	Dlg3 [cytosol] (R-RNO-6794232) Dlg3 [plasma membrane] (R-RNO-443609)	0.558	4
UniProt:Q05586-1 GRIN1			0.522	2
UniProt:P62139 PP1A			0.502	2
UniProt:Q5TCQ9 MAGI3			0.488	2