Lipophagy

Stable Identifier
R-HSA-9613354
Type
Pathway
Species
Homo sapiens
Compartment
autophagosome, autophagosome membrane, cytosol, lysosomal lumen, lysosomal membrane, phagocytic vesicle, phagocytic vesicle membrane, phagophore assembly site membrane
ReviewStatus
5/5
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Lipophagy
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Triglycerides stored in lipid droplets are hydrolysed under nutrient starvation to release fatty acids for energy. The content of lipid droplets may vary but they are all coated with a protective protein called perilipin. When this protein is degraded, lipid droplets associate with autophagic components and breakdown into fatty acids (Ward C et al. 2016, Schulze R J et al. 2017). This process is termed as lipophagy (Singh R et al. 2009).
Literature References
PubMed ID Title Journal Year
19339967 Autophagy regulates lipid metabolism

Singh, R, Kaushik, S, Wang, Y, Xiang, Y, Novak, I, Komatsu, M, Tanaka, K, Cuervo, AM, Czaja, MJ

Nature 2009
28642194 Breaking fat: The regulation and mechanisms of lipophagy

Schulze, RJ, Sathyanarayan, A, Mashek, DG

Biochim. Biophys. Acta 2017
26778751 Autophagy, lipophagy and lysosomal lipid storage disorders

Ward, C, Martinez-Lopez, N, Otten, EG, Carroll, B, Maetzel, D, Singh, R, Sarkar, S, Korolchuk, VI

Biochim. Biophys. Acta 2016
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
lipophagy (0061724)
Cross References
BioModels Database
Authored
Varusai, TM  (2019-02-21)
Reviewed
Metzakopian, E  (2019-02-22)
Created
Varusai, TM  (2018-07-13)
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