Reactome | Unwinding of DNA for the Nascent Transcript: Second Transition

Unwinding of DNA for the Nascent Transcript: Second Transition

Stable Identifier

R-HSA-9613494

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Unwinding of DNA for the Nascent Transcript: Second Transition

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The human BTF2 basic transcription factor (also called TFIIH), is required for class1 gene transcription of the second round of transcripts. TFIIH has an adenosine triphosphate-dependent DNA helicase activity. The helicase activity is closely associated with the multi-subunit BTF2/TFIIH transcription factor which also has a CTD protein kinase activity.

Literature References

PubMed ID	Title	Journal	Year
11784853	Translocation after synthesis of a four-nucleotide RNA commits RNA polymerase II to promoter escape. Goodrich, JA, Kugel, JF	Mol Cell Biol	2002
8465201	DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor Chambon, P, Roy, R, Hoeijmakers, JH, Egly, JM, Schaeffer, L, Humbert, S, Vermeulen, W, Moncollin, V	Science	1993
9405375	Three transitions in the RNA polymerase II transcription complex during initiation. Fiedler, U, Timmers, HT, Holstege, FC	EMBO J	1998