Reactome | Unwinding DNA for the nascent transcript

Unwinding DNA for the nascent transcript

Stable Identifier

R-HSA-9613497

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Unwinding DNA for the nascent transcript

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The human BTF2 basic transcription factor (also called TFIIH), is required for class1 gene transcription of transcripts. TFIIH has an adenosine triphosphate-dependent DNA helicase activity. The helicase activity is closely associated with the multi-subunit BTF2/TFIIH transcription factor which also has a CTD protein kinase activity.

Literature References

PubMed ID	Title	Journal	Year
11784853	Translocation after synthesis of a four-nucleotide RNA commits RNA polymerase II to promoter escape. Kugel, JF, Goodrich, JA	Mol Cell Biol	2002
8465201	DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor Schaeffer, L, Roy, R, Humbert, S, Moncollin, V, Vermeulen, W, Hoeijmakers, JH, Chambon, P, Egly, JM	Science	1993
9405375	Three transitions in the RNA polymerase II transcription complex during initiation. Holstege, FC, Fiedler, U, Timmers, HT	EMBO J	1998