Reactome | SOX10 [nucleoplasm]

SOX10 [nucleoplasm]

Stable Identifier

R-HSA-9613639

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcription factor SOX-10, SOX10_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P56693 SOX10

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Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type II Classical Cadherins (Homo sapiens)
        
        Regulation of CDH19 Expression and Function (Homo sapiens)
        
        SOX10 binds CDH19 gene promoter (Homo sapiens)
        
        SOX10 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P56693 SOX10

Gene Names

SOX10

Chain

chain:1-466

Reference Genes

BioGPS Gene:6663 SOX10

COSMIC (genes):SOX10 SOX10

CTD Gene:6663 SOX10

dbSNP Gene:6663 SOX10

ENSEMBL:ENSG00000100146 SOX10

ENSEMBL_homo_sapiens_GENE:ENSG00000100146.20 SOX10

HGNC:11190 SOX10

KEGG Gene (Homo sapiens):6663 SOX10

Monarch:6663 SOX10

NCBI Gene:6663 SOX10

OMIM:602229 SOX10

UCSC:P56693 SOX10

Reference Transcript

RefSeq:NM_006941.3 SOX10

Other Identifiers

11742810_at

11753116_a_at

16934881

209842_PM_at

209842_at

209843_PM_s_at

209843_s_at

36018_at

3960304

3960305

3960306

3960307

3960308

3960309

3960310

3960313

3960314

3960315

3960317

3960318

3960321

6663

8075992

A_23_P143694

A_24_P108784

GE79198

GO:0000122

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001216

GO:0001228

GO:0001701

GO:0001755

GO:0002009

GO:0002052

GO:0003677

GO:0003682

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005739

GO:0005741

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006368

GO:0007405

GO:0007422

GO:0009653

GO:0010626

GO:0010628

GO:0012501

GO:0014003

GO:0014015

GO:0016020

GO:0022010

GO:0023052

GO:0030154

GO:0030318

GO:0031643

GO:0032808

GO:0042802

GO:0043066

GO:0043226

GO:0045892

GO:0045893

GO:0045944

GO:0048469

GO:0048484

GO:0048546

GO:0048589

GO:0048709

GO:0048856

GO:0048863

GO:0048870

GO:0061138

GO:0071393

GO:0071466

GO:0090090

GO:0140110

GO:0140297

GO:1990837

GO:1990841

HMNXSV003024817

Hs.44317.0.S2_3p_at

ILMN_1653750

PH_hs_0024274

TC22000781.hg

g12803952_3p_a_at

Participates

as an input of

as a component of

Other forms of this molecule

p-T240,T244-SOX10 [nucleoplasm]

Inferred To

SOX10 [nucleoplasm] (Bos taurus)

SOX10 [nucleoplasm] (Canis familiaris)

SOX10 [nucleoplasm] (Gallus gallus)

SOX10 [nucleoplasm] (Sus scrofa)

Sox100B [nucleoplasm] (Drosophila melanogaster)

Homologues of SOX10 [nucleoplasm] (Sus scrofa)

Sox10 [nucleoplasm] (Mus musculus)

Sox10 [nucleoplasm] (Rattus norvegicus)

sox10 [nucleoplasm] (Danio rerio)

sox10 [nucleoplasm] (Xenopus tropicalis)

ste11 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_008872.1

OpenTargets

ENSG00000100146

GeneCards

P56693

HPA

ENSG00000100146-SOX10

Ensembl

ENSP00000380093, ENSP00000354130, ENSG00000100146, ENST00000396884, ENST00000360880

PRO

P56693

Pharos - Targets

P56693

Orphanet

15538

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17252 PRKCA	8	PRKCA [nucleoplasm] (R-HSA-450530) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [cytosol] (R-HSA-58196) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [plasma membrane] (R-HSA-156469) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292)	0.556	3
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:O43186 CRX			0.556	3
UniProt:Q8TAP4-4 LMO3			0.556	3
UniProt:Q15038 DAZP2			0.556	3
UniProt:P78424 PO6F2			0.556	3
UniProt:Q9ULV5-2 HSF4			0.556	3
UniProt:P62937-2 P629372			0.556	3
UniProt:Q15047-2 SETDB1			0.556	3
UniProt:Q5SWW7 CJ055			0.556	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.556	3
UniProt:P23760 PAX3	2	PAX3 [nucleoplasm] (R-HSA-9757859) PAX3 (1-319) [nucleoplasm] (R-HSA-5603237)	0.527	2
UniProt:P56693 SOX10	2	SOX10 [nucleoplasm] (R-HSA-9613639) p-T240,T244-SOX10 [nucleoplasm] (R-HSA-9824578)	0.527	2
UniProt:P20265 POU3F2	1	POU3F2 [nucleoplasm] (R-HSA-9613754)	0.527	3
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481)	0.508	2
UniProt:O00712 NFIB	1	NFIB [nucleoplasm] (R-HSA-60136)	0.471	2
UniProt:Q12857 NFIA	1	NFIA [nucleoplasm] (R-HSA-60134)	0.471	2

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