Chaperone Mediated Autophagy

Stable Identifier
R-HSA-9613829
DOI
10.3180/R-HSA-9613829.1
Type
Pathway
Species
Homo sapiens
Compartment
cytosol, lysosomal lumen, lysosomal membrane
ReviewStatus
5/5
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Chaperone Mediated Autophagy
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In contrary to the vesicle-mediated macroautophagy, the chaperone mediated mechanism of autophagy selectively targets individual proteins to the lysosome for degradation. Chaperones bind intracellular proteins based on recognition motifs and transports them from the cytosol to the lysosomal membrane. Subsequently, the protein is translocated into the lumen for digestion (Cuervo A M et al. 2014, Kaushik S et al. 2018).
Literature References
PubMed ID Title Journal Year
24281265 Chaperone-mediated autophagy: roles in disease and aging

Cuervo, AM, Wong, E

Cell Res. 2014
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Events
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as an event of
Event Information
Go Biological Process
chaperone-mediated autophagy (0061684)
Cross References
BioModels Database
Authored
Varusai, TM  (2019-02-21)
Reviewed
Metzakopian, E  (2019-02-22)
Created
Varusai, TM  (2018-07-19)
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