Viral UL47:UL48 Proteins Bind HCMV Tegumented Virion to Host Microtuble and Dynein complexs

Stable Identifier
R-HSA-9614343
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
ReviewStatus
5/5
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Tegument proteins help deliver the Human Cytomegalovirus (HCMV) genome-containing capsid to the nucleus during the viral entry process. Signals initiated upon receptor binding induce cellular antiviral responses but may also prime the cell for subsequent events during viral entry. The Capsid-associated tegument proteins UL47 and UL48 (and perhaps pp150) direct capsids along microtubules (MTs) toward nuclear pore complexes driven by cellular motor proteins such as dynein.
Literature References
PubMed ID Title Journal Year
18203656 Entry route of HCMV into endothelial cells

Sinzger, C

J. Clin. Virol. 2008
  Fields Virology

Knipe, DM, Howley, PM

  2013
12857923 Microtubule network facilitates nuclear targeting of human cytomegalovirus capsid

Miura, Y, Moriishi, E, Gibson, W, Sata, T, Irie, S, Tanaka, K, Ogawa-Goto, K, Kurata, T

J. Virol. 2003
Participants
Participates
Event Information
Catalyst Activity

microtubule binding activity of HCMV Tegumented Virion [viral tegument]

Disease
Name Identifier Synonyms
viral infectious disease DOID:934 Viral disease, virus infection, virus infection
Authored
Reviewed
Created
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