Reactome | 14-3-3 proteins bind AKT-phosphorylated FOXO3

14-3-3 proteins bind AKT-phosphorylated FOXO3

Stable Identifier

R-HSA-9614562

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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14-3-3 proteins bind AKT-phosphorylated FOXO3

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Nuclear exclusion and cytoplasmic retention of AKT-phosphorylated FOXO3 is promoted by binding of FOXO3 to 14-3-3 proteins: YWHAZ (14-3-3 zeta), YWHAQ (14-3-3 theta), and SFN (14-3-3 sigma) (Brunet et al. 1999, Arimoto-Ishida et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
10102273	Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor Hu, LS, Bonni, A, Brunet, A, Blenis, J, Zigmond, MJ, Anderson, MJ, Lin, MZ, Greenberg, ME, Juo, P, Arden, KC	Cell	1999
14701673	Inhibition of phosphorylation of a forkhead transcription factor sensitizes human ovarian cancer cells to cisplatin Takahashi, T, Ohshima, C, Arimoto-Ishida, E, Nishio, Y, Sakata, M, Ohmichi, M, Hayakawa, J, Tasaka, K, Kurachi, H, Murata, Y, Takahashi, K, Mabuchi, S, Kimura, A	Endocrinology	2004