Activation of Latent HCMV Genome

Stable Identifier
R-HSA-9614810
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
nucleoplasm
ReviewStatus
5/5
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Activation of Latent HCMV Genome
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A cell containing a repressed or latent Human Cytomegalovirus (HCMV) genome sits quietly carrying on its normal cellular functions. The HCMV silenced HCMV geneome can be activated by a number of celluar events or state changes. Reactivation of HCMV lytic infection is correlated to changes in histone modifications around the MIEP promoter resulting in a new chromatin structure conducive to transcriptional activity. These changes are intimately linked with cell differentiation, a phenomenon known to reactivate latent virus in vivo.
Literature References
PubMed ID Title Journal Year
19682613 Chromatin structure regulates human cytomegalovirus gene expression during latency, reactivation and lytic infection

Sinclair, J

Biochim. Biophys. Acta 2010
  Fields Virology

Knipe, DM, Howley, PM

  2013
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
viral infectious disease DOID:934 Viral disease, virus infection, virus infection
Authored
Gillespie, ME  (2018-07-25)
Reviewed
Streblow, DN  (2019-10-18)
Caposio, P  (2019-10-18)
Created
Gillespie, ME  (2018-07-28)
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