Reactome | EGR1 binds CDK5R1 gene

EGR1 binds CDK5R1 gene

Stable Identifier

R-HSA-9616105

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        NGF-stimulated transcription (Homo sapiens)
        
        EGR1 binds CDK5R1 gene (Homo sapiens)

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EGR1 binds to its cognate site in the promoter element of the CDK5R1 gene in response to sustained stimulation with NGF. Expression of CDK5R1 (also known as p35) depends on activation of the ERK signaling pathway downstream of NGF stimulation, and is required to promote neurite outgrowth (Harada et al, 2001). CDK5R1 is a neuron-specific activator of CDK5, and the CDK5:CDK5R1 complex is required for neuronal differentiation (Tsai et al, 1994; Lew et al, 1994; Nikolic et al, 1996; Xiong et al, 1997; Paglini et al, 1998).

Literature References

PubMed ID	Title	Journal	Year
9822744	Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth Kunda, P, Paglini, G, Morfini, G, Caceres, A, Maccioni, R, Pigino, G, Ferreira, A, Quiroga, S	J. Neurosci.	1998
9343422	Role of cyclins in neuronal differentiation of immortalized hippocampal cells Rosner, MR, Pestell, R, Xiong, W	Mol. Cell. Biol.	1997
8090222	A brain-specific activator of cyclin-dependent kinase 5 Lew, J, Wang, JH, Aebersold, R, Huang, QQ, Hunt, T, Qi, Z, Winkfein, RJ	Nature	1994
8090221	p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5 Chae, T, Caviness, VS, Harlow, E, Delalle, I, Tsai, LH	Nature	1994
11331872	ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1 Harada, T, Nishida, E, Ogawa, S, Morooka, T	Nat. Cell Biol.	2001
8846918	The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation Kwon, YT, Dudek, H, Tsai, LH, Nikolic, M, Ramos, YF	Genes Dev.	1996