Reactome | MyrG-CDK5R1,2 bind CDK5

MyrG-CDK5R1,2 bind CDK5

Stable Identifier

R-HSA-9616368

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        NGF-stimulated transcription (Homo sapiens)
        
        MyrG-CDK5R1,2 bind CDK5 (Homo sapiens)

General

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CDK5R1 is a neuron-specific regulatory subunit of CDK5 that activates CDK5 kinase activity in a cyclin-type manner and CDK5R1 and CDK5 co-precipitate from rat PC12 cells and from bovine brain (Tsai et al, 1994; Lew et al, 1994; Harada et al, 2001). CDK5 activity is required for neurite outgrowth and disruption of CDK5 or CDK5R1 leads to defects in neuronal migration in mice (Nikolic et al, 1996; Xiong et al, 1997; Paglini et al, 1998). A second CDK5 regulatory protein, CDK5R2 (also known as p39) is required for CDK5-dependent neurite outgrowth in response to bFGF (Tang et al, 1995; Xiong et al, 1997).

Literature References

PubMed ID	Title	Journal	Year
9822744	Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth Kunda, P, Paglini, G, Morfini, G, Caceres, A, Maccioni, R, Pigino, G, Ferreira, A, Quiroga, S	J. Neurosci.	1998
9343422	Role of cyclins in neuronal differentiation of immortalized hippocampal cells Rosner, MR, Pestell, R, Xiong, W	Mol. Cell. Biol.	1997
8090222	A brain-specific activator of cyclin-dependent kinase 5 Lew, J, Wang, JH, Aebersold, R, Huang, QQ, Hunt, T, Qi, Z, Winkfein, RJ	Nature	1994
11331872	ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1 Harada, T, Nishida, E, Ogawa, S, Morooka, T	Nat. Cell Biol.	2001
8090221	p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5 Chae, T, Caviness, VS, Harlow, E, Delalle, I, Tsai, LH	Nature	1994
8846918	The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation Kwon, YT, Dudek, H, Tsai, LH, Nikolic, M, Ramos, YF	Genes Dev.	1996
7592934	An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator Yeung, J, Matsushita, M, Tang, D, Matsui, H, Lee, KY, Wang, JH, Tomizawa, K, Hatase, O	J. Biol. Chem.	1995