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Go!
TXN [nucleoplasm]
Stable Identifier
R-HSA-9617732
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
Regulation of FOXO transcriptional activity by acetylation (Homo sapiens)
TXN disrupts FOXO4 complex with EP300 (Homo sapiens)
TXN [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10599 TXN
Gene Names
TXN, TRDX, TRX, TRX1
Chain
initiator methionine:, chain:2-105
Reference Genes
BioGPS Gene:7295 TXN
COSMIC (genes):TXN TXN
CTD Gene:7295 TXN
dbSNP Gene:7295 TXN
ENSEMBL:ENSG00000136810 TXN
HGNC:12435 TXN
KEGG:hsa:7295 TXN
Monarch:7295 TXN
NCBI Gene:7295 TXN
OMIM:187700 TXN
UCSC:P10599 TXN
Reference Transcript
RefSeq:NM_001244938.1 TXN
RefSeq:NM_003329.3 TXN
Other Identifiers
11715469_s_at
11715470_x_at
11750538_x_at
11753775_x_at
11753804_x_at
17097052
208864_PM_s_at
208864_s_at
3220157
3220158
3220159
3220160
3220162
3220163
3220166
3220168
3220174
3220175
36992_at
7295
8163185
A_23_P60248
GE81265
GO:0000122
GO:0003723
GO:0003824
GO:0004791
GO:0005515
GO:0005576
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006355
GO:0009314
GO:0015035
GO:0016209
GO:0016491
GO:0033138
GO:0042803
GO:0043226
GO:0043388
GO:0045454
GO:0046826
GO:0047134
GO:0051897
GO:0061692
GO:0070062
GO:0071731
GO:0098754
GO:0140096
GO:2000170
HMNXSV003001941
HMNXSV003052323
ILMN_1680314
ILMN_2038776
PH_hs_0030018
PH_hs_0040358
TC09001473.hg
X77584_at
g11345419_3p_at
g11345419_3p_s_at
Participates
as an input of
TXN disrupts Foxo4 comples with EP300 (Homo sapiens)
TXN disrupts FOXO4 complex with EP300 (Homo sapiens)
Other forms of this molecule
TXN [cytosol]
2xHC-TXN [cytosol]
2xHC-TXN [nucleoplasm]
Cross References
RefSeq
NP_003320.2
,
NP_001231867.1
OpenTargets
ENSG00000136810
ENSEMBL
ENSP00000363641
,
ENSP00000363639
,
ENST00000374517
,
ENST00000374515
ZINC - Substances
THIO_HUMAN
ZINC - Biogenic
THIO_HUMAN
ZINC target
P10599
PRO
P10599
GlyGen
P10599
PDB
2IFQ
,
3M9J
,
3E3E
,
3KD0
,
3M9K
,
4POK
,
4LL4
,
4TRX
,
4PUF
,
3QFA
,
4POL
,
3QFB
,
4POM
,
1ERW
,
2HSH
,
1TRU
,
2IIY
,
1TRS
,
1TRV
,
1MDJ
,
1MDI
,
1MDK
,
1ERT
,
1ERU
,
4OO4
,
4OO5
,
1AIU
,
1AUC
,
1CQG
,
1TRW
,
2HXK
,
1M7T
,
1ERV
,
1CQH
,
4LL1
,
3TRX
,
5DQY
ZINC - Investigational
THIO_HUMAN
HPA
ENSG00000136810-TXN
Pharos - Targets
P10599
ZINC - Predictions - Purchasable
THIO_HUMAN
Interactors (35)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.785
5
UniProt:Q9H3M7 TXNIP
2
TXNIP [cytosol]
(R-HSA-1250246)
TXNIP [nucleoplasm]
(R-HSA-9617747)
0.743
8
UniProt:Q92905 COPS5
2
COPS5 [nucleoplasm]
(R-HSA-5697019)
COPS5 [cytosol]
(R-HSA-416963)
0.736
9
UniProt:Q99683 MAP3K5
1
MAP3K5 [cytosol]
(R-HSA-167709)
0.677
4
UniProt:P04406 GAPDH
1
GAPDH [cytosol]
(R-HSA-70428)
0.675
4
UniProt:P42574 CASP3
5
CASP3(1-277) [cytosol]
(R-HSA-57021)
CASP3(29-175) [nucleoplasm]
(R-HSA-211194)
CASP3(176-277) [nucleoplasm]
(R-HSA-211203)
CASP3(29-175) [cytosol]
(R-HSA-141644)
CASP3(176-277) [cytosol]
(R-HSA-141646)
0.672
6
UniProt:D0ZRB2 SLRP
0.633
7
UniProt:Q99836 MYD88
8
MyD88 R196C [cytosol]
(R-HSA-5602329)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MYD88 [endosome membrane]
(R-HSA-975123)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [cytosol]
(R-HSA-166059)
0.602
4
UniProt:O95831 AIFM1
0.569
3
UniProt:P32119 PRDX2
2
p-T89-PRDX2 [cytosol]
(R-HSA-8868574)
PRDX2 [cytosol]
(R-HSA-3341292)
0.564
2
UniProt:Q12933 TRAF2
5
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
0.556
3
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
AKT1 [plasma membrane]
(R-HSA-199416)
AKT1 [cytosol]
(R-HSA-58252)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
0.556
3
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.556
3
UniProt:P19883 FST
1
FST [extracellular region]
(R-HSA-2473211)
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:Q9UJW9 SRTD3
0.556
3
UniProt:X5D778 X5D778
0.556
6
UniProt:Q9GZT8 NIF3L
0.556
3
UniProt:G5E9A7 G5E9A7
0.556
3
UniProt:P23560-2 BDNF
0.556
3
UniProt:P12814 ACTN1
3
ACTN1 [cytosol]
(R-HSA-354096)
ACTN1 [platelet alpha granule lumen]
(R-HSA-349724)
ACTN1 [extracellular region]
(R-HSA-349722)
0.556
3
UniProt:P07900 HSP90AA1
8
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
0.556
3
UniProt:P37198 NUP62
2
NUP62 [nuclear envelope]
(R-HSA-157713)
NUP62 [cytosol]
(R-HSA-9634226)
0.556
3
UniProt:Q8WXH2 JPH3
0.556
3
UniProt:P01023 A2M
2
A2M [extracellular region]
(R-HSA-49291)
A2M [platelet alpha granule lumen]
(R-HSA-139834)
0.556
3
UniProt:Q9NZD8 SPG21
0.556
6
UniProt:Q9Y605 MOFA1
0.556
3
UniProt:Q96D03 DDT4L
0.556
5
UniProt:Q9BXU3 TX13A
0.556
3
UniProt:Q14114-3 Q141143
0.556
3
UniProt:P50570-2 DNM2
0.556
3
UniProt:P51608 MECP2
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:Q5JTV8 TOR1AIP1
1
TOR1AIP1 [cytosol]
(R-HSA-9715083)
0.527
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
12
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