FOXO4:ATXN3 binds SOD2 gene promoter

Stable Identifier
R-HSA-9617832
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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FOXO4:ATXN3 binds SOD2 gene promoter
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Endogenous human FOXO4 and ATXN3 form a complex that binds to adjacent FOXO- and ATXN3- binding sites in the promoter of the SOD2 gene, encoding mitochondrial manganese-dependent superoxide dismutase (Araujo et al. 2011).
Literature References
PubMed ID Title Journal Year
21536589 FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3

Evert, BO, Araujo, J, Dorn, S, Dieringer, S, Wuellner, U, Krauss, S, Pfeifer, A, Klockgether, T, Breuer, P, Zimmermann, K

Hum. Mol. Genet. 2011
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Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Bertaggia, E  (2018-10-26)
Donlon, T  (2018-10-17)
Created
Orlic-Milacic, M  (2018-08-30)
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