SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1

Stable Identifier
R-HSA-9617833
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1
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FOXO3 directly stimulates transcription of the SOD2 gene, encoding mitochondrial manganese-dependent superoxide dismutase (Kops et al. 2002). FOXO4 and ATXN3, which form a complex, also directly stimulate SOD2 gene transcription (Araujo et al. 2011). Acetylation of FOXO4 by EP300 (p300) or CREBBP (CBP) in response to oxidative stress does not affect FOXO4-mediated induction of SOD2 gene transcription (Dansen et al. 2009). FOXO1 positively regulates SOD2 transcription (Hori et al. 2013, Guan et al. 2016), but direct binding of FOXO1 to the SOD2 gene promoter has not been demonstrated.
Literature References
PubMed ID Title Journal Year
24040102 Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress

Hosoda, R, Kuno, A, Horio, Y, Hori, YS

PLoS ONE 2013
27547294 CD38 Deficiency Protects the Heart from Ischemia/Reperfusion Injury through Activating SIRT1/FOXOs-Mediated Antioxidative Stress Pathway

Liu, XH, Jiang, K, Deng, KY, Xiao, YF, Guan, XH, Wang, LF, Ji, G, Zhao, N, Tang, L, Xin, HB, Fu, M, Qian, YS, Hong, X

Oxid Med Cell Longev 2016
12239572 Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

Medema, RH, Burgering, BM, Kops, GJ, Wirtz, KW, Polderman, PE, Dansen, TB, Bos, JL, Saarloos, I, Coffer, PJ, Huang, TT

Nature 2002
21536589 FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3

Evert, BO, Araujo, J, Dorn, S, Dieringer, S, Wuellner, U, Krauss, S, Pfeifer, A, Klockgether, T, Breuer, P, Zimmermann, K

Hum. Mol. Genet. 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
FOXO4:ATXN3:SOD2 gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXO4:ATXN3 [nucleoplasm]
Regulator
FOXO3:SOD2 gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXO3 [nucleoplasm]
Regulator
FOXO1 [nucleoplasm] (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Bertaggia, E  (2018-10-26)
Donlon, T  (2018-10-17)
Created
Orlic-Milacic, M  (2018-08-30)
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