FOXO1,FOXO3,FOXO4 bind CDKN1A gene promoter

Stable Identifier
R-HSA-9617840
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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FOXO1,FOXO3,FOXO4 bind CDKN1A gene promoter
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FOXO1, FOXO3 and FOXO4 can all bind to forkhead box elements in the promoter region of the CDKN1A gene, encoding CDK inhibitor p21Cip1 (Seoane et al. 2004, Tinkum et al. 2013).

Literature References
PubMed ID Title Journal Year
15084259 Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

Massague, J, Shen, L, Le, HV, Anderson, SA, Seoane, J

Cell 2004
23918930 Forkhead box O1 (FOXO1) protein, but not p53, contributes to robust induction of p21 expression in fasted mice

Piwnica-Worms, H, Herzog, E, White, LS, Marpegan, L, Piwnica-Worms, D, Tinkum, KL

J. Biol. Chem. 2013
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Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Bertaggia, E  (2018-10-26)
Donlon, T  (2018-10-17)
Created
Orlic-Milacic, M  (2018-08-30)
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