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CaMKK binds activated calmodulin in the cytosol
Stable Identifier
R-HSA-9619214
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
Activation of RAC1 downstream of NMDARs (Homo sapiens)
CaMKK binds activated calmodulin in the cytosol (Homo sapiens)
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Two isoforms of CaMKK, CAMKK1 (CaMKK alpha) and CAMKK2 (CaMKK beta) are expressed in the brain and involved in signaling downstream of the NMDA receptor (Schmitt et al. 2005, Mairet-Coello et al. 2013). CAMKK1 (Lee et al. 2010) and CAMKK2 (Kylarova et al. 2018) become catalytically active upon binding to the calcium-bound calmodulin (CALM1:4xCa2+). CAMKK1 and CAMKK2 localize to both cytosol and nucleus (Nakamura et al. 1996, Sakagami et al. 2000, Nakamura et al. 2001, Kitani et al. 2003).
Participants
Input
CALM1:4xCa2+ [cytosol]
(Homo sapiens)
CaMKK [cytosol]
(Homo sapiens)
Output
CaMKK:CALM1:4xCa2+ [cytosol]
(Homo sapiens)
Participates
as an event of
Activation of RAC1 downstream of NMDARs (Homo sapiens)
Inferred From
Camkk1 binds activated calmodulin in the cytosol (Homo sapiens)
Camkk2 binds activated calmodulin in the cytosol (Homo sapiens)
Authored
Mahajan, SS (2009-10-29)
Reviewed
Tukey, D (2009-11-18)
Hansen, KB (2018-11-02)
Yi, F (2018-11-02)
Created
Orlic-Milacic, M (2018-09-14)
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