AMPK phosphorylates MAPT

Stable Identifier
R-HSA-9619515
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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AMPK phosphorylates MAPT
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AMPK, activated by CAMKK2-mediated phosphorylation, phosphorylates MAPT (Tau) on serine residues S262, S356 and S396. AMPK-mediated phosphorylation changes microtubule binding properties of MAPT and is involved in development and maintenance of dendritic spines and synaptotoxicity of beta-amyloid oligomers (Thornton et al. 2011, Mairet-Coello et al. 2013).

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Catalyst Activity

protein serine/threonine kinase activity of p-AMPK heterotrimer [cytosol]

Physical Entity
p-AMPK heterotrimer [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
AMPK phosphorylates Mapt (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Created
Orlic-Milacic, M  (2018-09-18)
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