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MAPT-8 [cytosol]
Stable Identifier
R-HSA-9619519
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Microtubule-associated protein tau, Isoform Tau-F, TAU_HUMAN, Tau-F, Tau-4
Icon
Locations in the PathwayBrowser for interactor UniProt:P00338 LDHA
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
Activation of AMPK downstream of NMDARs (Homo sapiens)
AMPK negatively regulates binding of MAPT to microtubules (Homo sapiens)
MAPT-8 [cytosol] (Homo sapiens)
AMPK phosphorylates MAPT (Homo sapiens)
MAPT-8 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10636-8 MAPT
Gene Names
MAPT, MAPTL, MTBT1, TAU
Other Identifiers
113_i_at
114_r_at
11718731_a_at
11718732_a_at
11718733_a_at
11722667_a_at
11747246_a_at
11763486_a_at
16835016
203928_PM_x_at
203928_x_at
203929_PM_s_at
203929_s_at
203930_PM_s_at
203930_s_at
206401_PM_s_at
206401_s_at
225379_PM_at
225379_at
310_s_at
331_at
3723688
3723707
3723710
3723712
3723714
3723721
3723722
3723723
3723725
3723731
3723732
3723733
3723734
3723735
3723736
3723737
3723740
3723743
3723746
3723747
3723748
3723749
3723750
3723751
3723752
3723753
3723754
3723759
38629_at
4137
8007828
80210_at
A_14_P115066
A_14_P130889
A_14_P132491
A_21_P0014031
A_23_P207699
A_24_P224488
A_32_P95541
GE58740
GE86145
GO:0000226
GO:0001774
GO:0002376
GO:0003677
GO:0003680
GO:0003690
GO:0003697
GO:0003723
GO:0003779
GO:0005515
GO:0005576
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0005856
GO:0005874
GO:0005886
GO:0006475
GO:0006914
GO:0006919
GO:0006954
GO:0006974
GO:0007005
GO:0007010
GO:0007018
GO:0007267
GO:0007416
GO:0007611
GO:0007613
GO:0008017
GO:0008092
GO:0008289
GO:0010288
GO:0010506
GO:0010629
GO:0010917
GO:0015630
GO:0015631
GO:0016020
GO:0016072
GO:0016607
GO:0017124
GO:0019896
GO:0019899
GO:0019901
GO:0021954
GO:0023052
GO:0030154
GO:0030424
GO:0030425
GO:0030426
GO:0030673
GO:0030674
GO:0031110
GO:0031113
GO:0031116
GO:0031122
GO:0031175
GO:0032930
GO:0033044
GO:0033673
GO:0034063
GO:0034185
GO:0034330
GO:0034399
GO:0034452
GO:0034605
GO:0034614
GO:0035091
GO:0036211
GO:0036464
GO:0036477
GO:0042802
GO:0042995
GO:0043005
GO:0043025
GO:0043197
GO:0043226
GO:0043565
GO:0044297
GO:0044304
GO:0045121
GO:0045298
GO:0045773
GO:0046785
GO:0048143
GO:0048167
GO:0048312
GO:0048699
GO:0048856
GO:0050808
GO:0050848
GO:0050877
GO:0051087
GO:0051258
GO:0051260
GO:0051721
GO:0051879
GO:0060090
GO:0061564
GO:0065003
GO:0070507
GO:0071813
GO:0072386
GO:0090140
GO:0090258
GO:0097386
GO:0097418
GO:0097435
GO:0098930
GO:0099077
GO:0099609
GO:1900034
GO:1900452
GO:1902474
GO:1902936
GO:1902988
GO:1903748
GO:1903829
GO:1904115
GO:1904428
GO:1905689
GO:1990000
GO:1990090
GO:1990416
HMNXSV003034099
Hs.101174.4.A1_3p_at
ILMN_1710903
ILMN_2298727
ILMN_2310814
J03778_s_at
PH_hs_0005629
TC17000592.hg
TC17002241.hg
TC17_ctg5_hap1000017.hg
X14474_at
X61373_at
g338684_3p_a_at
g8400712_3p_a_at
Participates
as an input of
AMPK phosphorylates Mapt (Rattus norvegicus)
AMPK phosphorylates MAPT (Homo sapiens)
AMPK-negatively regulates binding of MAPT to microtubules (Bos taurus)
AMPK negatively regulates binding of MAPT to microtubules (Homo sapiens)
as a component of
MAPT-8:Microtubule [cytosol] (Bos taurus)
MAPT-8:Microtubule [cytosol] (Homo sapiens)
Other forms of this molecule
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
p-S262,S356,S396-MAPT-8 [cytosol]
Inferred To
Mapt [cytosol]
(Mus musculus)
Mapt [cytosol]
(Rattus norvegicus)
MAPT [cytosol]
(Canis familiaris)
MAPT [cytosol]
(Sus scrofa)
MAPT-8 [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_058519.3
,
NP_058518.1
,
NP_001190181.1
,
NP_005901.2
,
NP_001116538.2
,
NP_058525.1
,
NP_001116539.1
ZINC - World Drugs
TAU_HUMAN
OpenTargets
ENSG00000186868
ZINC - FDA approved
TAU_HUMAN
ZINC - Substances
TAU_HUMAN
ZINC - Biogenic
TAU_HUMAN
ZINC target
P10636
PRO
P10636
PDB
5ZV3
,
8SEH
,
8Q8R
,
7QK2
,
8Q9G
,
7P68
,
7QKF
,
5ZIA
,
7QKZ
,
8OHP
,
8Q8X
,
3OVL
,
5E2W
,
8FUG
,
6GK7
,
7SP1
,
7NRS
,
8OTH
,
8Q99
,
8Q9I
,
7QJX
,
8Q8D
,
8BGS
,
6FBW
,
5N5B
,
7P6D
,
2ON9
,
8P34
,
6QJP
,
4Y5I
,
6TJX
,
8Q2L
,
6QJH
,
7UPE
,
8OI0
,
8ORG
,
7QKL
,
6BB4
,
5HF3
,
7EYC
,
7P65
,
8OPI
,
8Q98
,
7QKY
,
8PII
,
7QJW
,
8OHI
,
8Q9C
,
5DMG
,
6DCA
,
7P6C
,
8Q9M
,
7P67
,
8Q9F
,
7QJZ
,
8ORF
,
4GLR
,
7QKK
,
8OP0
,
6N4P
,
8Q9E
,
8Q8C
,
5MO3
,
7YPG
,
8Q8W
,
7QK6
,
6QJM
,
6DC8
,
5MP5
,
8G58
,
8CAX
,
5MP3
,
8Q7L
,
6QJQ
,
7QL3
,
5N5A
,
6PXR
,
7PQP
,
8Q2K
,
7U0Z
,
7QL4
,
7QK1
,
8Q7M
,
6CVJ
,
5O3T
,
8OT9
,
8Q9K
,
6VH7
,
8Q8M
,
8QCR
,
7NRX
,
7R5H
,
8Q7F
,
6HRF
,
8Q8L
,
7NRQ
,
5O3L
,
4NP8
,
6NWP
,
8Q8F
,
8QJJ
,
7QKU
,
8ORE
,
8OTJ
,
6ODG
,
7QJV
,
8Q9B
,
7R4T
,
6GK8
,
8Q27
,
7QK5
,
8OTG
,
8Q88
,
6FI5
,
6LRA
,
8Q9D
,
7QKX
,
8Q7T
,
7MKG
,
7UPG
,
6HRE
,
6CVN
,
7NRV
,
4Y3B
,
8Q97
,
5V5C
,
6XLI
,
7KQK
,
7P6B
,
4E0O
,
8G55
,
8Q8U
,
6VI3
,
7QKH
,
7MKH
,
8OH2
,
5O3O
,
8R3T
,
8BYN
,
8KDX
,
6TJO
,
8Q8Z
,
7QL2
,
6NWQ
,
7QKI
,
4E0M
,
8Q2J
,
6GX5
,
8AZU
,
8Q8Y
,
8Q8E
,
8BGV
,
7MKF
,
8Q9H
,
7QK3
,
8OTC
,
4E0N
,
7QKV
,
8G54
,
6VHA
,
7QL0
,
8Q9L
,
8CAQ
,
7QKG
,
7PQC
,
8Q7P
,
7QJY
,
7QKW
,
5NVB
,
8Q9A
,
4Y32
,
7P6A
,
7P6E
,
7QKM
,
7YMN
,
8OTI
,
4TQE
,
5K7N
,
8SEI
,
7QKJ
,
5MP1
,
8FYU
,
2MZ7
,
8OT6
,
1I8H
,
6DC9
,
7NRT
,
8FNZ
,
7P66
,
8Q8V
,
4FL5
,
6NK4
,
5V5B
,
7QL1
,
8Q9J
,
5E2V
,
8Q8S
,
6H06
,
8PPO
,
7UPF
,
8QCP
,
8Q92
,
8Q9O
,
6VHL
ZINC - Investigational
TAU_HUMAN
ZINC - Metabolites
TAU_HUMAN
HPA
ENSG00000186868-MAPT
GeneCards
P10636
Ensembl
ENST00000703922
,
ENST00000620818
,
ENSP00000515557
,
ENSP00000408975
,
ENSP00000479142
,
ENSP00000443028
,
ENST00000574436
,
ENST00000622728
,
ENSP00000481769
,
ENST00000334239
,
ENST00000628393
,
ENSG00000276155
,
ENSP00000483784
,
ENSP00000487819
,
ENSP00000413056
,
ENSP00000482244
,
ENSP00000303214
,
ENST00000613360
,
ENSP00000410838
,
ENST00000634049
,
ENSP00000487570
,
ENST00000351559
,
ENSP00000505258
,
ENST00000621329
,
ENSG00000186868
,
ENSP00000458742
,
ENST00000680542
,
ENST00000571987
,
ENSP00000488373
,
ENST00000633047
,
ENSP00000484491
,
ENST00000415613
,
ENST00000703924
,
ENSP00000487837
,
ENSP00000515558
,
ENSP00000389250
,
ENST00000612872
,
ENSP00000515559
,
ENST00000420682
,
ENST00000703978
,
ENSP00000484321
,
ENSP00000478602
,
ENSP00000477703
,
ENSP00000515600
,
ENST00000620981
,
ENST00000626571
,
ENST00000620070
,
ENST00000631447
,
ENST00000431008
,
ENST00000703923
,
ENSP00000460965
,
ENSP00000488245
,
ENST00000535772
,
ENSG00000277956
,
ENST00000446361
,
ENST00000632500
,
ENSP00000334886
,
ENST00000622106
,
ENSP00000486039
Pharos - Targets
P10636
ZINC - Predictions - Purchasable
TAU_HUMAN
Orphanet
16379
Interactors (30)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.749
8
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.723
8
UniProt:P05067-PRO_0000000092 APP
0.71
5
UniProt:P10636 MAPT
3
MAPT(422-758) [cytosol]
(R-HSA-350642)
MAPT(2-421) [cytosol]
(R-HSA-350628)
MAPT [cytosol]
(R-HSA-201574)
0.673
3
UniProt:P11142 HSPA8
10
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.667
6
UniProt:P49841 GSK3B
4
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [nucleoplasm]
(R-HSA-2022823)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [cytosol]
(R-HSA-2997551)
0.656
4
IntAct:EBI-4399559 UBIQ
0.641
3
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.589
3
UniProt:O43583 DENR
0.564
2
UniProt:Q8TCE9 PPL13
0.556
3
UniProt:O15195-2 O151952
0.556
3
UniProt:Q92608-2 Q926082
0.556
3
UniProt:Q9HC96 CAPN10
1
CAPN10 [cytosol]
(R-HSA-8848640)
0.556
3
UniProt:Q9C0A1 ZFHX2
0.556
3
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.547
2
UniProt:P02649-PRO_0000001987 APOE
0.544
3
UniProt:P51674 GPM6A
0.527
2
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.524
2
UniProt:P46779 RPL28
1
RPL28 [cytosol]
(R-HSA-72444)
0.499
4
UniProt:Q9UNE7-1 STUB1
0.499
5
UniProt:Q9UPY8 MARE3
0.499
3
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.499
2
UniProt:P04156 PRNP
2
PRNP [cytosol]
(R-HSA-9617597)
PRNP [plasma membrane]
(R-HSA-375060)
0.499
2
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.483
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.483
2
UniProt:Q9NY61 AATF
1
AATF [cytosol]
(R-HSA-205071)
0.471
2
UniProt:P07237 P4HB
3
P4HB [endoplasmic reticulum lumen]
(R-HSA-174692)
p-P4HB [endoplasmic reticulum lumen]
(R-HSA-8956902)
HC53,56-P4HB [endoplasmic reticulum lumen]
(R-HSA-3341287)
0.463
2
UniProt:P43004 SLC1A2
1
SLC1A2 [plasma membrane]
(R-HSA-210459)
0.462
4
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