Reactome | MAPT-8 [cytosol]

MAPT-8 [cytosol]

Stable Identifier

R-HSA-9619519

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Microtubule-associated protein tau, Isoform Tau-F, TAU_HUMAN, Tau-F, Tau-4

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Locations in the PathwayBrowser for interactor UniProt:Q02878 RPL6

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External Reference Information

External Reference

UniProt:P10636-8 MAPT

Gene Names

MAPT, MAPTL, MTBT1, TAU

Participates

as an input of

as a component of

Other forms of this molecule

p-S262,S356,S396-MAPT-8 [cytosol]

p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]

Inferred To

Mapt [cytosol] (Mus musculus)

Mapt [cytosol] (Rattus norvegicus)

MAPT [cytosol] (Canis familiaris)

MAPT [cytosol] (Sus scrofa)

MAPT-8 [cytosol] (Dictyostelium discoideum)

Cross References

OpenTargets

ENSG00000186868

ENSEMBL

ENSP00000410838, ENSP00000389250, ENSP00000515559, ENSP00000303214, ENSP00000515557, ENSP00000488373, ENSP00000505258, ENSP00000477703, ENST00000634049, ENST00000703978, ENSG00000186868, ENST00000351559, ENST00000535772, ENSP00000484491, ENST00000620070, ENST00000612872, ENST00000631447, ENSP00000460965, ENST00000622728, ENST00000680542, ENST00000420682, ENST00000613360, ENSP00000481769, ENST00000431008, ENSP00000487570, ENST00000703923, ENST00000703922, ENSP00000484321, ENST00000621329, ENSP00000482244, ENSP00000487837, ENST00000446361, ENSP00000515558, ENSP00000334886, ENST00000620981, ENSP00000515600, ENST00000632500, ENSP00000443028, ENSP00000458742, ENSP00000413056, ENSP00000408975, ENST00000415613, ENSG00000277956, ENSP00000486039, ENSP00000483784, ENST00000334239, ENST00000574436, ENSP00000479142, ENST00000633047, ENST00000622106, ENST00000571987, ENSG00000276155, ENSP00000478602, ENST00000626571, ENST00000620818, ENST00000628393, ENST00000703924, ENSP00000488245, ENSP00000487819

ZINC - FDA approved

TAU_HUMAN

ZINC - Substances

TAU_HUMAN

ZINC - Biogenic

TAU_HUMAN

ZINC target

P10636

PRO

P10636

GlyGen

P10636

PDB

6VHA, 8QCP, 7UPF, 8Q7P, 8G58, 7QL4, 8OTH, 6DC9, 6GK7, 7R5H, 8Q8E, 7QK5, 9EO7, 6HRE, 8WCP, 8OHP, 5NVB, 5MP3, 8Q2L, 8ORF, 9BBL, 7P6B, 8GCK, 8Q9F, 8Q9O, 7PQP, 7P67, 8BGV, 9GG6, 7QKK, 8P34, 8R3T, 7UPG, 6CVJ, 7QKY, 5HF3, 9G13, 8KDX, 7QJX, 4E0O, 7QL0, 8Q8Y, 8Q92, 9BXQ, 6QJH, 7QK6, 8OTJ, 6VHL, 5MP5, 6HRF, 8OT6, 5N5B, 7P6E, 5K7N, 1I8H, 4FL5, 8Q9L, 7MKG, 8Q9G, 5O3T, 7NRV, 7NRX, 8Q27, 9BXI, 8Q7F, 8Q8R, 8Q8Z, 8UQ7, 7QK3, 6VI3, 8FNZ, 7QKG, 7QL1, 5ZIA, 7QKX, 8Q2J, 8OT9, 4Y32, 8ORG, 8OP0, 6NK4, 8AZU, 8Q9M, 7MKH, 8QJJ, 5O3L, 7P68, 9GG0, 8OH2, 6GX5, 6ODG, 7QKL, 7QK1, 9BXR, 7QJY, 7QKZ, 8Q8W, 8Q8U, 6NWP, 6XLI, 8Q7T, 7YMN, 8Q8F, 8TTN, 8Q9B, 8Q9J, 8FYU, 9BBM, 9ERN, 4GLR, 8Q9D, 7MKF, 6QJP, 4TQE, 8CAQ, 7NRS, 7UPE, 6CVN, 7NRQ, 7QKI, 7QL2, 8Q98, 6FBW, 7QK2, 8G54, 8Q7L, 9EO9, 7QKH, 7QKM, 8FUG, 6NWQ, 6QJM, 8ZX6, 7QKU, 4Y3B, 5V5C, 6LRA, 8TTL, 9EOE, 8Q9K, 7PQC, 9CGX, 9ERO, 9EOG, 2MZ7, 7EYC, 6QJQ, 8QDV, 7P65, 5E2W, 8BGS, 7QKJ, 4E0M, 8OPI, 8Q8X, 9BXO, 7U0Z, 7QKF, 7QJV, 9CZL, 8Q8V, 8Q7M, 2ON9, 8Q8M, 8Q8C, 5V5B, 7P6C, 8Q9H, 8Q9C, 5ZV3, 6FI5, 8Q9E, 8BYN, 5O3O, 6H06, 9GG1, 8ZWM, 5E2V, 8PPO, 6N4P, 6TJX, 8Q88, 4E0N, 7QJZ, 8OHI, 6PXR, 6DCA, 8Q99, 7QL3, 8G55, 6GK8, 8Q97, 8OTC, 6VH7, 4NP8, 8SEH, 7QKV, 8SEI, 7P6D, 8PII, 8Q9I, 5DMG, 9CGZ, 9EOH, 7YPG, 7NRT, 5MO3, 8QCR, 8ZWL, 4Y5I, 6DC8, 9CZI, 8OTG, 8OTI, 8CAX, 7KQK, 7QJW, 6BB4, 7QKW, 8OI0, 8Q8L, 7SP1, 8Q8S, 5N5A, 8Q2K, 5MP1, 8Q8D, 3OVL, 8ORE, 7P6A, 8Q9A, 9ERM, 7R4T, 6TJO, 7P66

ZINC - Investigational

TAU_HUMAN

ZINC - Metabolites

TAU_HUMAN

GeneCards

MAPT

HPA

ENSG00000186868-MAPT

Pharos - Targets

P10636

Orphanet

MAPT

ZINC - Predictions - Purchasable

TAU_HUMAN

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.749	8
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.723	8
UniProt:P05067-PRO_0000000092 APP			0.71	5
UniProt:P10636 MAPT	3	MAPT [cytosol] (R-HSA-201574) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT(422-758) [cytosol] (R-HSA-350642)	0.673	3
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.667	6
UniProt:P49841 GSK3B	4	GSK3B [cytosol] (R-HSA-2997551) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [nucleoplasm] (R-HSA-2022823) GSK3B del304-316 [cytosol] (R-HSA-5339682)	0.656	4
IntAct:EBI-4399559 UBIQ			0.641	3
UniProt:P06241 FYN	6	FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y531-FYN [cytosol] (R-HSA-391819) p-S21,Y420-FYN [cytosol] (R-HSA-5218745)	0.589	3
UniProt:O43583 DENR			0.564	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.556	3
UniProt:Q9C0A1 ZFHX2			0.556	3
UniProt:Q9HC96 CAPN10	1	CAPN10 [cytosol] (R-HSA-8848640)	0.556	3
UniProt:Q92608-2 Q926082			0.556	3
UniProt:O15195-2 O151952			0.556	3
UniProt:Q8TCE9 PPL13			0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.547	2
UniProt:P02649-PRO_0000001987 APOE			0.544	3
UniProt:P51674 GPM6A			0.527	2
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.524	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.499	2
UniProt:P04156 PRNP	2	PRNP [plasma membrane] (R-HSA-375060) PRNP [cytosol] (R-HSA-9617597)	0.499	2
UniProt:Q9UPY8 MARE3			0.499	3
UniProt:Q9UNE7-1 STUB1			0.499	5
UniProt:P46779 RPL28	1	RPL28 [cytosol] (R-HSA-72444)	0.499	4
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.483	2
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.483	2
UniProt:Q9NY61 AATF	1	AATF [cytosol] (R-HSA-205071)	0.471	2
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.463	2
UniProt:P43004 SLC1A2	1	SLC1A2 [plasma membrane] (R-HSA-210459)	0.462	4

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