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p-S262,S356,S396-MAPT-8 [cytosol]
Stable Identifier
R-HSA-9619521
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S262,S356,S396-Tau-F, p-S262,S356,S396-Tau-4
Icon
Locations in the PathwayBrowser for interactor UniProt:O60749 SNX2
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
Activation of AMPK downstream of NMDARs (Homo sapiens)
AMPK phosphorylates MAPT (Homo sapiens)
p-S262,S356,S396-MAPT-8 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10636-8 MAPT
Gene Names
MAPT, MAPTL, MTBT1, TAU
Participates
as an output of
AMPK phosphorylates Mapt (Rattus norvegicus)
AMPK phosphorylates MAPT (Homo sapiens)
Other forms of this molecule
MAPT-8 [cytosol]
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
Modified Residues
Name
O-phospho-L-serine at 262
Coordinate
262
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 356
Coordinate
356
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 396
Coordinate
396
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Interactors (30)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.749
8
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.723
8
UniProt:P05067-PRO_0000000092 APP
0.71
5
UniProt:P10636 MAPT
3
MAPT(422-758) [cytosol]
(R-HSA-350642)
MAPT(2-421) [cytosol]
(R-HSA-350628)
MAPT [cytosol]
(R-HSA-201574)
0.673
3
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.667
6
UniProt:P49841 GSK3B
4
GSK3B [cytosol]
(R-HSA-2997551)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [nucleoplasm]
(R-HSA-2022823)
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
0.656
4
IntAct:EBI-4399559 UBIQ
0.641
3
UniProt:P06241 FYN
6
FYN [cytosol]
(R-HSA-200917)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y531-FYN [cytosol]
(R-HSA-391819)
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
0.589
3
UniProt:O43583 DENR
0.564
2
UniProt:Q8TCE9 PPL13
0.556
3
UniProt:O15195-2 O151952
0.556
3
UniProt:Q92608-2 Q926082
0.556
3
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.556
3
UniProt:Q9HC96 CAPN10
1
CAPN10 [cytosol]
(R-HSA-8848640)
0.556
3
UniProt:Q9C0A1 ZFHX2
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.547
2
UniProt:P02649-PRO_0000001987 APOE
0.544
3
UniProt:P51674 GPM6A
0.527
2
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.524
2
UniProt:P04156 PRNP
2
PRNP [cytosol]
(R-HSA-9617597)
PRNP [plasma membrane]
(R-HSA-375060)
0.499
2
UniProt:P46779 RPL28
1
RPL28 [cytosol]
(R-HSA-72444)
0.499
4
UniProt:Q9UNE7-1 STUB1
0.499
5
UniProt:Q9UPY8 MARE3
0.499
3
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
AKT1 [plasma membrane]
(R-HSA-199416)
AKT1 [cytosol]
(R-HSA-58252)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
0.499
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.483
2
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.483
2
UniProt:Q9NY61 AATF
1
AATF [cytosol]
(R-HSA-205071)
0.471
2
UniProt:P07237 P4HB
3
P4HB [endoplasmic reticulum lumen]
(R-HSA-174692)
p-P4HB [endoplasmic reticulum lumen]
(R-HSA-8956902)
HC53,56-P4HB [endoplasmic reticulum lumen]
(R-HSA-3341287)
0.463
2
UniProt:P43004 SLC1A2
1
SLC1A2 [plasma membrane]
(R-HSA-210459)
0.462
4
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