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p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
Stable Identifier
R-HSA-9619869
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phospho(S218,T356,S360,S377,T570,T730)-Ribosomal protein S6 kinase alpha 2, p-S218,T356,S360,S377,T570,T730-RSK3
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
RSK activation (Homo sapiens)
PDPK1 phosphorylates RSKs (Homo sapiens)
p-S221,T359.S363,S380,T573,T732-RSK [cytosol] (Homo sapiens)
p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol] (Homo sapiens)
p-S363,S380,T573 RS6K translocates to the nucleus (Homo sapiens)
p-S221,T359.S363,S380,T573,T732-RSK [cytosol] (Homo sapiens)
p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15349 RPS6KA2
Gene Names
RPS6KA2, MAPKAPK1C, RSK3
Chain
chain:1-733
Reference Genes
BioGPS Gene:6196 RPS6KA2
COSMIC (genes):RPS6KA2 RPS6KA2
CTD Gene:6196 RPS6KA2
dbSNP Gene:6196 RPS6KA2
ENSEMBL:ENSG00000071242 RPS6KA2
HGNC:10431 RPS6KA2
KEGG:hsa:6196 RPS6KA2
Monarch:6196 RPS6KA2
NCBI Gene:6196 RPS6KA2
OMIM:601685 RPS6KA2
UCSC:Q15349 RPS6KA2
Reference Transcript
RefSeq:NM_001318936.1 RPS6KA2
RefSeq:NM_021135.5 RPS6KA2
RefSeq:NM_001318938.1 RPS6KA2
RefSeq:NM_001006932.2 RPS6KA2
RefSeq:NM_001318937.1 RPS6KA2
Other Identifiers
11731762_s_at
11731763_s_at
11743831_s_at
11756657_a_at
1557970_PM_s_at
1557970_s_at
17025664
204906_PM_at
204906_at
212912_PM_at
212912_at
2984665
2984666
2984667
2984668
2984669
2984670
2984671
2984672
2984673
2984674
2984675
2984677
2984678
2984679
2984680
2984683
2984685
2984691
2984695
2984697
2984698
2984703
2984706
2984707
2984708
2984720
2984722
2984730
2984733
2984736
2984742
2984743
2984744
2984754
2984759
2984786
2984787
2984799
2984800
2984810
2984811
2984812
2984813
2984814
2984881
2984883
2984936
32892_at
33325_at
54736_at
6196
8130739
A_23_P335920
A_33_P3347452
A_33_P3399935
A_33_P3399943
GE82591
GE86143
GO:0000287
GO:0003824
GO:0004672
GO:0004674
GO:0004711
GO:0004712
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005840
GO:0006468
GO:0007165
GO:0007268
GO:0008285
GO:0016740
GO:0023052
GO:0035556
GO:0043065
GO:0043226
GO:0045202
GO:0045786
GO:0046872
GO:0106310
GO:0140096
HMNXSV003031331
HMNXSV003058235
Hs.184581.0.A1_3p_at
Hs2.397210.1.S1_3p_s_at
ILMN_1702501
ILMN_1716218
ILMN_1790801
PH_hs_0015556
TC06002310.hg
TC06004057.hg
X85106_at
g12803118_3p_at
Participates
as a member of
p-S221,T359.S363,S380,T573,T732-RSK [cytosol] (Homo sapiens)
Other forms of this molecule
p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm]
p-T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
p-T356,S360,T570-RPS6KA2 [cytosol]
RPS6KA2 [cytosol]
p-4S,T356,T570-RPS6KA2 [nucleoplasm]
RPS6KA2 [nucleoplasm]
Inferred To
phospho-RPS6KA2 [cytosol]
(Canis familiaris)
phospho-RPS6KA2 [cytosol]
(Gallus gallus)
phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
(Bos taurus)
phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
(Caenorhabditis elegans)
phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
(Dictyostelium discoideum)
phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
(Drosophila melanogaster)
phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
(Mus musculus)
phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
(Rattus norvegicus)
phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
(Saccharomyces cerevisiae)
phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
(Schizosaccharomyces pombe)
phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
(Sus scrofa)
phospho-p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 218
Coordinate
218
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 356
Coordinate
356
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 360
Coordinate
360
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 377
Coordinate
377
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 570
Coordinate
570
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 730
Coordinate
730
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001006933.2
,
NP_001305866.1
,
NP_001305865.1
,
NP_001305867.1
,
NP_066958.2
ZINC - World Drugs
KS6A2_HUMAN
Guide to Pharmacology - Targets
1529
OpenTargets
ENSG00000071242
ENSEMBL
ENST00000265678
,
ENSP00000265678
,
ENSP00000427015
,
ENST00000503859
ZINC - FDA approved
KS6A2_HUMAN
ZINC - Substances
KS6A2_HUMAN
ZINC - Biogenic
KS6A2_HUMAN
ZINC target
Q15349
PRO
Q15349
ZINC - Investigational
KS6A2_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000071242-RPS6KA2
Pharos - Targets
Q15349
ZINC - Predictions - Purchasable
KS6A2_HUMAN
HMDB Protein
HMDBP01159
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P28482 MAPK1
18
p-T185,Y187-MAPK1 [nucleoplasm]
(R-HSA-112354)
p-T185,Y187-MAPK1 [cytosol]
(R-HSA-109853)
MAPK1 [cytosol]
(R-HSA-59282)
MAPK1 [nucleoplasm]
(R-HSA-199960)
p-T185-MAPK1 [cytosol]
(R-HSA-9635773)
p-T185,Y187 MAPK1 P58G [cytosol]
(R-HSA-9652802)
p-T185,Y187 MAPK1 E322A [cytosol]
(R-HSA-9652794)
p-T185,Y187 MAPK1 D321N [cytosol]
(R-HSA-9652785)
p-T185,Y187 MAPK1 D321V [cytosol]
(R-HSA-9652791)
p-T185,Y187 MAPK1 P58L [cytosol]
(R-HSA-9652806)
p-T185,Y187 MAPK1 S142L [cytosol]
(R-HSA-9652808)
p-T185,Y187 MAPK1 E81K [cytosol]
(R-HSA-9652799)
p-T185,Y187 MAPK1 E322K [cytosol]
(R-HSA-9652175)
p-T185,Y187 MAPK1 E322V [cytosol]
(R-HSA-9652797)
MAPK1 [azurophil granule lumen]
(R-HSA-6799225)
MAPK1 [extracellular region]
(R-HSA-6806250)
MAPK1 [ficolin-1-rich granule lumen]
(R-HSA-6800964)
MAPK1 [endoplasmic reticulum lumen]
(R-HSA-9636293)
0.914
12
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.769
9
UniProt:Q15418 RPS6KA1
7
p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm]
(R-HSA-444292)
p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619993)
p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619871)
p-T359,S363,T573-RPS6KA1 [cytosol]
(R-HSA-9619957)
RPS6KA1 [cytosol]
(R-HSA-444256)
p-4S,T359,T573-RPS6KA1 [nucleoplasm]
(R-HSA-199829)
RPS6KA1 [nucleoplasm]
(R-HSA-199860)
0.725
5
UniProt:P27361 MAPK3
6
p-T202,Y204-MAPK3 [nucleoplasm]
(R-HSA-112359)
p-T202,Y204-MAPK3 [cytosol]
(R-HSA-109842)
MAPK3 [cytosol]
(R-HSA-59284)
MAPK3 [nucleoplasm]
(R-HSA-73724)
p-T202-MAPK3 [cytosol]
(R-HSA-9635775)
MAPK3 [endoplasmic reticulum lumen]
(R-HSA-9636295)
0.706
5
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:Q12849 GRSF1
2
GRSF1 [mitochondrial matrix]
(R-HSA-9837006)
GRSF1 [cytosol]
(R-HSA-192689)
0.527
2
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