RSKs autophosphorylate

Stable Identifier
R-HSA-9620004
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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RSKs autophosphorylate
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Upon phosphorylation by activated ERKs, ribosomal S6 kinases (RSKs) autophosphorylate on conserved serine residue in the linker region (S380 in RPS6KA1) and a conserved threonine residue at the C-terminal ERK-docking domain (T732 in RPS6KA1) (Dalby et al. 1998, Roux et al. 2003). Autophosphorylation at the ERK-docking domain regulates binding to ERK and duration of RSK activity (Roux et al. 2003).
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Catalyst Activity

protein serine/threonine kinase activity of p-T359,S363,T573-RSK [cytosol]

Physical Entity
p-T359,S363,T573-RSK [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Rps6ka1 autophosphorylates (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Created
Orlic-Milacic, M  (2018-09-19)
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